Mogućnosti citologije u diferencijalnoj dijagnozi tiroidnog nodusa
Fine-needle aspiration biopsy (FNAB) plays an important role in the evaluation of thyroid nodules and the selection of patients for surgical treatment. It is complementary with clinical, ultrasonographical, radionuclid and radiographic investigations in the assessment of true nature of thyroid nodul...
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| Format: | Article |
| Language: | English |
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Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor
2011-01-01
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| Series: | Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor" |
| Subjects: | |
| Online Access: | http://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2011/1452-09231140019T.pdf |
| _version_ | 1818193113822265344 |
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| author | Tatić Svetislav Havelka-Đuković Marija Dunđerović Duško |
| author_facet | Tatić Svetislav Havelka-Đuković Marija Dunđerović Duško |
| author_sort | Tatić Svetislav |
| collection | DOAJ |
| description | Fine-needle aspiration biopsy (FNAB) plays an important role in the evaluation of thyroid nodules and the selection of patients for surgical treatment. It is complementary with clinical, ultrasonographical, radionuclid and radiographic investigations in the assessment of true nature of thyroid nodule. Cytological findings can be classified as non-representative, suspicious, benign or malignant or into 8 diagnostic categories: benign colloid nodules, cystis lesions, different types of thyroiditis, cellular microfollicular lesions, Hurthle-cell lesions, primary malignant tumors, other lesions and the non-diagnostic category. FNAB is successful in the diagnosis of benign cystic thyroid lesions, Hashimoto thyroiditis, anaplastic and papillary thyroid carcinoma, while it is less precise in the diagnosis of medullary carcinoma, lymphoma and secondary thyroid tumors. Follicular, as well as, Hurthle-cell thyroid carcinoma cannot be cytologically differentiated from follicular and Hurthle-cell adenoma of the thyroid gland. Immunocytochemistry may facilitate the diagnosis of thyroid tumors with follicular origin, applying galectin-3, cytokeratin 19 and HBME-1, whereas medullary thyroid carcinoma is typically proved with calcitonin immunostaining. |
| first_indexed | 2024-12-12T00:41:14Z |
| format | Article |
| id | doaj.art-82bdfbcf52cc4b5f8ebb2dbe92001eb8 |
| institution | Directory Open Access Journal |
| issn | 1821-1925 2406-131X |
| language | English |
| last_indexed | 2024-12-12T00:41:14Z |
| publishDate | 2011-01-01 |
| publisher | Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor |
| record_format | Article |
| series | Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor" |
| spelling | doaj.art-82bdfbcf52cc4b5f8ebb2dbe92001eb82022-12-22T00:44:14ZengSpecijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma ZlatiborMedicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor"1821-19252406-131X2011-01-011640192410.5937/medgla1140019T1452-09231140019TMogućnosti citologije u diferencijalnoj dijagnozi tiroidnog nodusaTatić Svetislav0Havelka-Đuković Marija1Dunđerović Duško2University of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Belgrade, SerbiaFine-needle aspiration biopsy (FNAB) plays an important role in the evaluation of thyroid nodules and the selection of patients for surgical treatment. It is complementary with clinical, ultrasonographical, radionuclid and radiographic investigations in the assessment of true nature of thyroid nodule. Cytological findings can be classified as non-representative, suspicious, benign or malignant or into 8 diagnostic categories: benign colloid nodules, cystis lesions, different types of thyroiditis, cellular microfollicular lesions, Hurthle-cell lesions, primary malignant tumors, other lesions and the non-diagnostic category. FNAB is successful in the diagnosis of benign cystic thyroid lesions, Hashimoto thyroiditis, anaplastic and papillary thyroid carcinoma, while it is less precise in the diagnosis of medullary carcinoma, lymphoma and secondary thyroid tumors. Follicular, as well as, Hurthle-cell thyroid carcinoma cannot be cytologically differentiated from follicular and Hurthle-cell adenoma of the thyroid gland. Immunocytochemistry may facilitate the diagnosis of thyroid tumors with follicular origin, applying galectin-3, cytokeratin 19 and HBME-1, whereas medullary thyroid carcinoma is typically proved with calcitonin immunostaining.http://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2011/1452-09231140019T.pdfthyroid nodulecytologyimmunocytochemistry |
| spellingShingle | Tatić Svetislav Havelka-Đuković Marija Dunđerović Duško Mogućnosti citologije u diferencijalnoj dijagnozi tiroidnog nodusa Medicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor" thyroid nodule cytology immunocytochemistry |
| title | Mogućnosti citologije u diferencijalnoj dijagnozi tiroidnog nodusa |
| title_full | Mogućnosti citologije u diferencijalnoj dijagnozi tiroidnog nodusa |
| title_fullStr | Mogućnosti citologije u diferencijalnoj dijagnozi tiroidnog nodusa |
| title_full_unstemmed | Mogućnosti citologije u diferencijalnoj dijagnozi tiroidnog nodusa |
| title_short | Mogućnosti citologije u diferencijalnoj dijagnozi tiroidnog nodusa |
| title_sort | mogucnosti citologije u diferencijalnoj dijagnozi tiroidnog nodusa |
| topic | thyroid nodule cytology immunocytochemistry |
| url | http://scindeks-clanci.ceon.rs/data/pdf/1821-1925/2011/1452-09231140019T.pdf |
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