Novel Biological Activities of Allosamidins
Allosamidins, which are secondary metabolites of the Streptomyces species, have chitin-mimic pseudotrisaccharide structures. They bind to catalytic centers of all family 18 chitinases and inhibit their enzymatic activity. Allosamidins have been used as chitinase inhibitors to investigate the physiol...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-06-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/6/6952 |
| _version_ | 1818515861178155008 |
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| author | Shohei Sakuda Hiromasa Inoue Hiromichi Nagasawa |
| author_facet | Shohei Sakuda Hiromasa Inoue Hiromichi Nagasawa |
| author_sort | Shohei Sakuda |
| collection | DOAJ |
| description | Allosamidins, which are secondary metabolites of the Streptomyces species, have chitin-mimic pseudotrisaccharide structures. They bind to catalytic centers of all family 18 chitinases and inhibit their enzymatic activity. Allosamidins have been used as chitinase inhibitors to investigate the physiological roles of chitinases in a variety of organisms. Two prominent biological activities of allosamidins were discovered, where one has anti-asthmatic activity in mammals, while the other has the chitinase-production- promoting activity in allosamidin-producing Streptomyces. In this article, recent studies on the novel biological activities of allosamidins are reviewed. |
| first_indexed | 2024-12-11T00:34:22Z |
| format | Article |
| id | doaj.art-82be09c9e1db49bb91375a8e4bdf6da9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T00:34:22Z |
| publishDate | 2013-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-82be09c9e1db49bb91375a8e4bdf6da92022-12-22T01:27:13ZengMDPI AGMolecules1420-30492013-06-011866952696810.3390/molecules18066952Novel Biological Activities of AllosamidinsShohei SakudaHiromasa InoueHiromichi NagasawaAllosamidins, which are secondary metabolites of the Streptomyces species, have chitin-mimic pseudotrisaccharide structures. They bind to catalytic centers of all family 18 chitinases and inhibit their enzymatic activity. Allosamidins have been used as chitinase inhibitors to investigate the physiological roles of chitinases in a variety of organisms. Two prominent biological activities of allosamidins were discovered, where one has anti-asthmatic activity in mammals, while the other has the chitinase-production- promoting activity in allosamidin-producing Streptomyces. In this article, recent studies on the novel biological activities of allosamidins are reviewed.http://www.mdpi.com/1420-3049/18/6/6952allosamidinchitinaseinhibitorasthmaStreptomycessecondary metabolite |
| spellingShingle | Shohei Sakuda Hiromasa Inoue Hiromichi Nagasawa Novel Biological Activities of Allosamidins Molecules allosamidin chitinase inhibitor asthma Streptomyces secondary metabolite |
| title | Novel Biological Activities of Allosamidins |
| title_full | Novel Biological Activities of Allosamidins |
| title_fullStr | Novel Biological Activities of Allosamidins |
| title_full_unstemmed | Novel Biological Activities of Allosamidins |
| title_short | Novel Biological Activities of Allosamidins |
| title_sort | novel biological activities of allosamidins |
| topic | allosamidin chitinase inhibitor asthma Streptomyces secondary metabolite |
| url | http://www.mdpi.com/1420-3049/18/6/6952 |
| work_keys_str_mv | AT shoheisakuda novelbiologicalactivitiesofallosamidins AT hiromasainoue novelbiologicalactivitiesofallosamidins AT hiromichinagasawa novelbiologicalactivitiesofallosamidins |