The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species.

The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species.

The high-risk human papillomavirus (HPV) E6 proteins are consistently expressed in HPV-associated lesions and cancers. HPV16 E6 sustains the activity of the mTORC1 and mTORC2 signaling cascades under conditions of growth factor deprivation. Here we report that HPV16 E6 activated mTORC1 by enhanced s...

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Bibliographic Details
Main Authors: Jennifer M Spangle, Karl Munger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3597533?pdf=render

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