Anti - HIV-1 integrase activity of Thai Medicinal Plants
For the purpose of discovering anti-HIV-1 agents from natural sources, the aqueous and EtOH extracts of eight Thaiplants including Clerodendron indicum (whole plant), Tiliacora triandra (stem), Capparis micracantha (wood), Harrissoniaperforata (wood), Ficus glomerata (wood), Diospyros decandra (wood...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Prince of Songkla University
2009-08-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | http://www.rdoapp.psu.ac.th/html/sjst/journal/31-3/0125-3395-31-3-289-292.pdf |
| _version_ | 1811343286050226176 |
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| author | Kingkan Bunluepuech Supinya Tewtrakul |
| author_facet | Kingkan Bunluepuech Supinya Tewtrakul |
| author_sort | Kingkan Bunluepuech |
| collection | DOAJ |
| description | For the purpose of discovering anti-HIV-1 agents from natural sources, the aqueous and EtOH extracts of eight Thaiplants including Clerodendron indicum (whole plant), Tiliacora triandra (stem), Capparis micracantha (wood), Harrissoniaperforata (wood), Ficus glomerata (wood), Diospyros decandra (wood), Dracaena loureiri (heartwood), and Tinospora crispa (stem) were screened for their inhibitory activities against HIV-1 integrase (IN) using the multiplate integration assay(MIA). Of the EtOH extracts, Ficus glomerata (wood) was the most potent with an IC50 value of 7.8 g/ml; whereas the water extract of Harrisonia perforata (wood) was the most potent aqueous extract with an IC50 value of 2.3 g/ml. The isolation of active principles against HIV-1 IN from Ficus glomerata is now actively pursued. |
| first_indexed | 2024-04-13T19:25:45Z |
| format | Article |
| id | doaj.art-82bf7913e5aa47d18c5e76b68fdc3394 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-04-13T19:25:45Z |
| publishDate | 2009-08-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-82bf7913e5aa47d18c5e76b68fdc33942022-12-22T02:33:22ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952009-08-01313289292Anti - HIV-1 integrase activity of Thai Medicinal PlantsKingkan BunluepuechSupinya TewtrakulFor the purpose of discovering anti-HIV-1 agents from natural sources, the aqueous and EtOH extracts of eight Thaiplants including Clerodendron indicum (whole plant), Tiliacora triandra (stem), Capparis micracantha (wood), Harrissoniaperforata (wood), Ficus glomerata (wood), Diospyros decandra (wood), Dracaena loureiri (heartwood), and Tinospora crispa (stem) were screened for their inhibitory activities against HIV-1 integrase (IN) using the multiplate integration assay(MIA). Of the EtOH extracts, Ficus glomerata (wood) was the most potent with an IC50 value of 7.8 g/ml; whereas the water extract of Harrisonia perforata (wood) was the most potent aqueous extract with an IC50 value of 2.3 g/ml. The isolation of active principles against HIV-1 IN from Ficus glomerata is now actively pursued.http://www.rdoapp.psu.ac.th/html/sjst/journal/31-3/0125-3395-31-3-289-292.pdfAnti-HIV-1 integrase activityThai plants<i>Ficus glomerata</i><i>Harrisonia perforata</i> |
| spellingShingle | Kingkan Bunluepuech Supinya Tewtrakul Anti - HIV-1 integrase activity of Thai Medicinal Plants Songklanakarin Journal of Science and Technology (SJST) Anti-HIV-1 integrase activity Thai plants <i>Ficus glomerata</i> <i>Harrisonia perforata</i> |
| title | Anti - HIV-1 integrase activity of Thai Medicinal Plants |
| title_full | Anti - HIV-1 integrase activity of Thai Medicinal Plants |
| title_fullStr | Anti - HIV-1 integrase activity of Thai Medicinal Plants |
| title_full_unstemmed | Anti - HIV-1 integrase activity of Thai Medicinal Plants |
| title_short | Anti - HIV-1 integrase activity of Thai Medicinal Plants |
| title_sort | anti hiv 1 integrase activity of thai medicinal plants |
| topic | Anti-HIV-1 integrase activity Thai plants <i>Ficus glomerata</i> <i>Harrisonia perforata</i> |
| url | http://www.rdoapp.psu.ac.th/html/sjst/journal/31-3/0125-3395-31-3-289-292.pdf |
| work_keys_str_mv | AT kingkanbunluepuech antihiv1integraseactivityofthaimedicinalplants AT supinyatewtrakul antihiv1integraseactivityofthaimedicinalplants |