Oncologic Outcomes of Clinical N0 in Early Stage Oral Cancer Undergoing Elective Neck Dissection, Radiation, or Observation
Objective: Surgery, radiation, and observation are the practical N0 neck management. Among these modalities, the most promising management has not been concluded yet. We aimed to evaluate oncologic outcomes comparing among the modalities in clinically N0 early stage oral cancer. Material and Methods...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2013-08-01
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| Series: | Journal of Health Science and Medical Research (JHSMR) |
| Subjects: | |
| Online Access: | https://www.jhsmr.org/index.php/jhsmr/article/view/256 |
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| author | Kitti Jantharapattana Manupol Tangthongkum Hutcha Sriplung Vitoon Leelamanit |
| author_facet | Kitti Jantharapattana Manupol Tangthongkum Hutcha Sriplung Vitoon Leelamanit |
| author_sort | Kitti Jantharapattana |
| collection | DOAJ |
| description | Objective: Surgery, radiation, and observation are the practical N0 neck management. Among these modalities, the most promising management has not been concluded yet. We aimed to evaluate oncologic outcomes comparing among the modalities in clinically N0 early stage oral cancer.
Material and Methods: Clinicopathological data of 236 patients, who were diagnosed as T1 or T2, N0 squamous cell carcinoma of the oral cavity, were retrospectively reviewed. The eligible patients were classified into three groups regarding to the neck management whether elective neck dissection, elective neck radiation, or observation. Oncologic outcomes were evaluated at 5 years.
Results: Five-year overall survival rates were 77.7% for neck dissection group, 58.8% for the radiation group and 76.5 % for the observation group (p=0.197). Five-year disease specific survival rates for the same three groups were 77.7%, 70.3% and 80.9%, respectively (p=0.339), while the 5-year regional disease free survival rates were 84.6%, 79.4% and 61.3% (p=0.062), respectively. The occult regional metastasis rate was 24.4%. In subgroup analysis regarding to T stage, the occult regional metastasis rate of T1 stage was 15.38 %, and the occult regional metastasis rate of T2 stage was 28.57%.
Conclusion: The differences of oncologic outcomes of clinical N0 in early stage oral cancer undergoing elective neck dissection, radiation, and observation are not statistically significant. |
| first_indexed | 2024-12-11T22:49:16Z |
| format | Article |
| id | doaj.art-82c13067169c4fffbf68f4048a2b4a50 |
| institution | Directory Open Access Journal |
| issn | 2586-9981 2630-0559 |
| language | English |
| last_indexed | 2024-12-11T22:49:16Z |
| publishDate | 2013-08-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Journal of Health Science and Medical Research (JHSMR) |
| spelling | doaj.art-82c13067169c4fffbf68f4048a2b4a502022-12-22T00:47:30ZengPrince of Songkla UniversityJournal of Health Science and Medical Research (JHSMR)2586-99812630-05592013-08-01314167177270Oncologic Outcomes of Clinical N0 in Early Stage Oral Cancer Undergoing Elective Neck Dissection, Radiation, or ObservationKitti Jantharapattana0Manupol Tangthongkum1Hutcha Sriplung2Vitoon Leelamanit3Department of Otolarynglogy Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,Department of Otolarynglogy Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,Department of Otolarynglogy Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110,Objective: Surgery, radiation, and observation are the practical N0 neck management. Among these modalities, the most promising management has not been concluded yet. We aimed to evaluate oncologic outcomes comparing among the modalities in clinically N0 early stage oral cancer. Material and Methods: Clinicopathological data of 236 patients, who were diagnosed as T1 or T2, N0 squamous cell carcinoma of the oral cavity, were retrospectively reviewed. The eligible patients were classified into three groups regarding to the neck management whether elective neck dissection, elective neck radiation, or observation. Oncologic outcomes were evaluated at 5 years. Results: Five-year overall survival rates were 77.7% for neck dissection group, 58.8% for the radiation group and 76.5 % for the observation group (p=0.197). Five-year disease specific survival rates for the same three groups were 77.7%, 70.3% and 80.9%, respectively (p=0.339), while the 5-year regional disease free survival rates were 84.6%, 79.4% and 61.3% (p=0.062), respectively. The occult regional metastasis rate was 24.4%. In subgroup analysis regarding to T stage, the occult regional metastasis rate of T1 stage was 15.38 %, and the occult regional metastasis rate of T2 stage was 28.57%. Conclusion: The differences of oncologic outcomes of clinical N0 in early stage oral cancer undergoing elective neck dissection, radiation, and observation are not statistically significant.https://www.jhsmr.org/index.php/jhsmr/article/view/256clinical n0elective neck dissectionelective neck radiationobservationoral cancer |
| spellingShingle | Kitti Jantharapattana Manupol Tangthongkum Hutcha Sriplung Vitoon Leelamanit Oncologic Outcomes of Clinical N0 in Early Stage Oral Cancer Undergoing Elective Neck Dissection, Radiation, or Observation Journal of Health Science and Medical Research (JHSMR) clinical n0 elective neck dissection elective neck radiation observation oral cancer |
| title | Oncologic Outcomes of Clinical N0 in Early Stage Oral Cancer Undergoing Elective Neck Dissection, Radiation, or Observation |
| title_full | Oncologic Outcomes of Clinical N0 in Early Stage Oral Cancer Undergoing Elective Neck Dissection, Radiation, or Observation |
| title_fullStr | Oncologic Outcomes of Clinical N0 in Early Stage Oral Cancer Undergoing Elective Neck Dissection, Radiation, or Observation |
| title_full_unstemmed | Oncologic Outcomes of Clinical N0 in Early Stage Oral Cancer Undergoing Elective Neck Dissection, Radiation, or Observation |
| title_short | Oncologic Outcomes of Clinical N0 in Early Stage Oral Cancer Undergoing Elective Neck Dissection, Radiation, or Observation |
| title_sort | oncologic outcomes of clinical n0 in early stage oral cancer undergoing elective neck dissection radiation or observation |
| topic | clinical n0 elective neck dissection elective neck radiation observation oral cancer |
| url | https://www.jhsmr.org/index.php/jhsmr/article/view/256 |
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