Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears
Pseudomonas aeruginosa is one of the common gram-negative organisms that cause severe invasive infections in different organ systems. P. aeruginosa has unique intrinsic mechanisms to develop antimicrobial resistance quickly, making it extremely difficult to treat. We report a case of extensively dru...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250923001634 |
| _version_ | 1797692060230221824 |
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| author | Taylor Wang Sumeet Jain Yoav Glidai Prachi Dua Katharine S. Dempsey Eric Shakin David S. Chu Marcia Epstein Lawrence G. Ha |
| author_facet | Taylor Wang Sumeet Jain Yoav Glidai Prachi Dua Katharine S. Dempsey Eric Shakin David S. Chu Marcia Epstein Lawrence G. Ha |
| author_sort | Taylor Wang |
| collection | DOAJ |
| description | Pseudomonas aeruginosa is one of the common gram-negative organisms that cause severe invasive infections in different organ systems. P. aeruginosa has unique intrinsic mechanisms to develop antimicrobial resistance quickly, making it extremely difficult to treat. We report a case of extensively drug-resistant (XDR) P. aeruginosa panophthalmitis due to contaminated artificial tears. This report investigates the role of systemic and intravitreal antimicrobials, summarizes the resistance mechanisms of P. aeruginosa, and provides an overview on cefiderocol, a novel antimicrobial that targets multidrug-resistant (MDR) and XDR Gram-negative pathogens. |
| first_indexed | 2024-03-12T02:22:14Z |
| format | Article |
| id | doaj.art-82c140c36f5a44389df0de915f053963 |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-03-12T02:22:14Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-82c140c36f5a44389df0de915f0539632023-09-06T04:51:15ZengElsevierIDCases2214-25092023-01-0133e01839Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tearsTaylor Wang0Sumeet Jain1Yoav Glidai2Prachi Dua3Katharine S. Dempsey4Eric Shakin5David S. Chu6Marcia Epstein7Lawrence G. Ha8Dayton and Karen Brown Division of Infectious Diseases, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 400 Community Dr, Manhasset, NY 11030, USA; Corresponding author.Department of Pharmacy, North Shore University Hospital, 300 Community Dr, Manhasset, NY 11030, USADepartment of Ophthalmology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 300 Community Dr, Manhasset, NY 11030, USADepartment of Ophthalmology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 300 Community Dr, Manhasset, NY 11030, USADepartment of Ophthalmology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 300 Community Dr, Manhasset, NY 11030, USADepartment of Ophthalmology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 300 Community Dr, Manhasset, NY 11030, USAInstitute of Ophthalmology and Visual Science, New Jersey Medical School of Rutgers University, 90 Bergen St., Newark, NJ 07103, USA; Metropolitan Eye Research and Surgery Institute, 540 Bergen Blvd., Palisades Park, NJ 07650, USADayton and Karen Brown Division of Infectious Diseases, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 400 Community Dr, Manhasset, NY 11030, USADayton and Karen Brown Division of Infectious Diseases, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 400 Community Dr, Manhasset, NY 11030, USAPseudomonas aeruginosa is one of the common gram-negative organisms that cause severe invasive infections in different organ systems. P. aeruginosa has unique intrinsic mechanisms to develop antimicrobial resistance quickly, making it extremely difficult to treat. We report a case of extensively drug-resistant (XDR) P. aeruginosa panophthalmitis due to contaminated artificial tears. This report investigates the role of systemic and intravitreal antimicrobials, summarizes the resistance mechanisms of P. aeruginosa, and provides an overview on cefiderocol, a novel antimicrobial that targets multidrug-resistant (MDR) and XDR Gram-negative pathogens.http://www.sciencedirect.com/science/article/pii/S2214250923001634Pseudomonas aeruginosaMultidrug-resistant organismVIM resistance geneGES resistance geneEndophthalmitis |
| spellingShingle | Taylor Wang Sumeet Jain Yoav Glidai Prachi Dua Katharine S. Dempsey Eric Shakin David S. Chu Marcia Epstein Lawrence G. Ha Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears IDCases Pseudomonas aeruginosa Multidrug-resistant organism VIM resistance gene GES resistance gene Endophthalmitis |
| title | Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears |
| title_full | Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears |
| title_fullStr | Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears |
| title_full_unstemmed | Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears |
| title_short | Extensively drug-resistant Pseudomonas aeruginosa panophthalmitis from contaminated artificial tears |
| title_sort | extensively drug resistant pseudomonas aeruginosa panophthalmitis from contaminated artificial tears |
| topic | Pseudomonas aeruginosa Multidrug-resistant organism VIM resistance gene GES resistance gene Endophthalmitis |
| url | http://www.sciencedirect.com/science/article/pii/S2214250923001634 |
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