Integration of Ligand-Based and Structure-Based Methods for the Design of Small-Molecule TLR7 Antagonists

Integration of Ligand-Based and Structure-Based Methods for the Design of Small-Molecule TLR7 Antagonists

Toll-like receptor 7 (TLR7) is activated in response to the binding of single-stranded RNA. Its over-activation has been implicated in several autoimmune disorders, and thus, it is an established therapeutic target in such circumstances. TLR7 small-molecule antagonists are not yet available for ther...

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Bibliographic Details
Main Authors: Sourav Pal, Uddipta Ghosh Dastidar, Trisha Ghosh, Dipyaman Ganguly, Arindam Talukdar
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
drug design
QSAR
pharmacophore model
molecular dynamics
TLR7 antagonists
Online Access:https://www.mdpi.com/1420-3049/27/13/4026

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