Fmr1 exon 14 skipping in late embryonic development of the rat forebrain

Fmr1 exon 14 skipping in late embryonic development of the rat forebrain

Abstract Background Fragile X syndrome, the major cause of inherited intellectual disability among men, is due to deficiency of the synaptic functional regulator FMR1 protein (FMRP), encoded by the FMRP translational regulator 1 (FMR1) gene. FMR1 alternative splicing produces distinct transcripts th...

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Main Authors: Juliana C. Corrêa-Velloso, Alessandra M. Linardi, Talita Glaser, Fernando J. Velloso, Maria P. Rivas, Renata E P. Leite, Lea T. Grinberg, Henning Ulrich, Michael R. Akins, Silvana Chiavegatto, Luciana A. Haddad
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Neuroscience
Subjects:
Fmr1
Fragile X syndrome-alternative splicing
Nervous system
Forebrain
Cerebellum
Nonsense-mediated decay (NMD)
Online Access:https://doi.org/10.1186/s12868-022-00711-1

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