Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese Women
(1) Background: Obesity is a major global public health concern as it is associated with many of the leading causes of preventable deaths. Exercise reduces obesity-induced inflammation; however, it is unknown how exercise training may impact mucosal associated invariant T (MAIT) cells in overweight/...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Sports |
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| Online Access: | https://www.mdpi.com/2075-4663/9/10/133 |
| _version_ | 1797513141457780736 |
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| author | Lauren C. Bates Erik D. Hanson Michael M. Levitt Bryan Richie Elise Erickson David B. Bartlett Melody D. Phillips |
| author_facet | Lauren C. Bates Erik D. Hanson Michael M. Levitt Bryan Richie Elise Erickson David B. Bartlett Melody D. Phillips |
| author_sort | Lauren C. Bates |
| collection | DOAJ |
| description | (1) Background: Obesity is a major global public health concern as it is associated with many of the leading causes of preventable deaths. Exercise reduces obesity-induced inflammation; however, it is unknown how exercise training may impact mucosal associated invariant T (MAIT) cells in overweight/obese (OW) post-menopausal women. Therefore, the purpose of this study was to investigate (i) circulating MAIT-cells at rest in OW vs. Lean women, (ii) the response of MAIT-cells to a single bout of combined aerobic and resistance exercise, and (iii) the effects of 12 weeks of exercise training (EX) or educational program (ED) on the MAIT-cell response in OW. (2) Methods: OW completed an acute exercise session or sitting control, underwent 12 weeks of exercise training or received educational materials, and then repeated the exercise session/sitting control. Lean post-menopausal women provided a baseline comparison. (3) Results: OW had lower circulating MAIT-cells at rest than Lean prior to exercise training; however, after training EX displayed improved MAIT-cell frequency. Additionally, prior to training EX did not exhibit MAIT-cell mobilization/egress, however, both improved after training. (4) Conclusions: Reduced MAIT-cell frequency and ability to mobilize/egress were potentially partially rescued in EX after 12 weeks of exercise training; however, further research is needed to elucidate age or obesity-induced attenuations in MAIT-cells. |
| first_indexed | 2024-03-10T06:12:29Z |
| format | Article |
| id | doaj.art-82c1bc71faec48e88631bb66efe26427 |
| institution | Directory Open Access Journal |
| issn | 2075-4663 |
| language | English |
| last_indexed | 2024-03-10T06:12:29Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sports |
| spelling | doaj.art-82c1bc71faec48e88631bb66efe264272023-11-22T20:01:26ZengMDPI AGSports2075-46632021-09-0191013310.3390/sports9100133Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese WomenLauren C. Bates0Erik D. Hanson1Michael M. Levitt2Bryan Richie3Elise Erickson4David B. Bartlett5Melody D. Phillips6Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, NC 27599, USADepartment of Exercise and Sport Science, University of North Carolina, Chapel Hill, NC 27599, USADepartment of Kinesiology, Texas Christian University, Fort Worth, TX 76109, USADepartment of Kinesiology, Texas Christian University, Fort Worth, TX 76109, USADepartment of Kinesiology, Texas Christian University, Fort Worth, TX 76109, USADuke Molecular Physiology Institute, Duke University, Durham, NC 27701, USADepartment of Kinesiology, Texas Christian University, Fort Worth, TX 76109, USA(1) Background: Obesity is a major global public health concern as it is associated with many of the leading causes of preventable deaths. Exercise reduces obesity-induced inflammation; however, it is unknown how exercise training may impact mucosal associated invariant T (MAIT) cells in overweight/obese (OW) post-menopausal women. Therefore, the purpose of this study was to investigate (i) circulating MAIT-cells at rest in OW vs. Lean women, (ii) the response of MAIT-cells to a single bout of combined aerobic and resistance exercise, and (iii) the effects of 12 weeks of exercise training (EX) or educational program (ED) on the MAIT-cell response in OW. (2) Methods: OW completed an acute exercise session or sitting control, underwent 12 weeks of exercise training or received educational materials, and then repeated the exercise session/sitting control. Lean post-menopausal women provided a baseline comparison. (3) Results: OW had lower circulating MAIT-cells at rest than Lean prior to exercise training; however, after training EX displayed improved MAIT-cell frequency. Additionally, prior to training EX did not exhibit MAIT-cell mobilization/egress, however, both improved after training. (4) Conclusions: Reduced MAIT-cell frequency and ability to mobilize/egress were potentially partially rescued in EX after 12 weeks of exercise training; however, further research is needed to elucidate age or obesity-induced attenuations in MAIT-cells.https://www.mdpi.com/2075-4663/9/10/133exercise immunologyaerobic exerciseresistance trainingoverweightobesitypost-menopausal |
| spellingShingle | Lauren C. Bates Erik D. Hanson Michael M. Levitt Bryan Richie Elise Erickson David B. Bartlett Melody D. Phillips Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese Women Sports exercise immunology aerobic exercise resistance training overweight obesity post-menopausal |
| title | Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese Women |
| title_full | Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese Women |
| title_fullStr | Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese Women |
| title_full_unstemmed | Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese Women |
| title_short | Mucosal-Associated Invariant T Cell Response to Acute Exercise and Exercise Training in Older Obese Women |
| title_sort | mucosal associated invariant t cell response to acute exercise and exercise training in older obese women |
| topic | exercise immunology aerobic exercise resistance training overweight obesity post-menopausal |
| url | https://www.mdpi.com/2075-4663/9/10/133 |
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