Myeloid Cells in Glioblastoma Microenvironment
Glioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is notoriously resistant to immunotherapy mainly due to its unique immune microenvironment. High dimensional data analysis reveals the extensive heterogeneity of immune components making up the GBM microenvironme...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/1/18 |
| _version_ | 1797543641302958080 |
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| author | Alessandra De Leo Alessio Ugolini Filippo Veglia |
| author_facet | Alessandra De Leo Alessio Ugolini Filippo Veglia |
| author_sort | Alessandra De Leo |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is notoriously resistant to immunotherapy mainly due to its unique immune microenvironment. High dimensional data analysis reveals the extensive heterogeneity of immune components making up the GBM microenvironment. Myeloid cells are the most predominant contributors to the GBM microenvironment; these cells are critical regulators of immune and therapeutic responses to GBM. Here, we will review the most recent advances on the characteristics and functions of different populations of myeloid cells in GBM, including bone marrow-derived macrophages, microglia, myeloid-derived suppressor cells, dendritic cells, and neutrophils. Epigenetic, metabolic, and phenotypic peculiarities of microglia and bone marrow-derived macrophages will also be assessed. The final goal of this review will be to provide new insights into novel therapeutic approaches for specific targeting of myeloid cells to improve the efficacy of current treatments in GBM patients. |
| first_indexed | 2024-03-10T13:48:30Z |
| format | Article |
| id | doaj.art-82c2ccf6572349959620fddc6c20e6d2 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T13:48:30Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-82c2ccf6572349959620fddc6c20e6d22023-11-21T02:24:21ZengMDPI AGCells2073-44092020-12-011011810.3390/cells10010018Myeloid Cells in Glioblastoma MicroenvironmentAlessandra De Leo0Alessio Ugolini1Filippo Veglia2Department of Immuno-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-9416, USADepartment of Immuno-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-9416, USADepartment of Immuno-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-9416, USAGlioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is notoriously resistant to immunotherapy mainly due to its unique immune microenvironment. High dimensional data analysis reveals the extensive heterogeneity of immune components making up the GBM microenvironment. Myeloid cells are the most predominant contributors to the GBM microenvironment; these cells are critical regulators of immune and therapeutic responses to GBM. Here, we will review the most recent advances on the characteristics and functions of different populations of myeloid cells in GBM, including bone marrow-derived macrophages, microglia, myeloid-derived suppressor cells, dendritic cells, and neutrophils. Epigenetic, metabolic, and phenotypic peculiarities of microglia and bone marrow-derived macrophages will also be assessed. The final goal of this review will be to provide new insights into novel therapeutic approaches for specific targeting of myeloid cells to improve the efficacy of current treatments in GBM patients.https://www.mdpi.com/2073-4409/10/1/18myeloid cellstumor-associated macrophagesmicroglianeutrophilsdendritic cellsmyeloid-derived suppressor cells |
| spellingShingle | Alessandra De Leo Alessio Ugolini Filippo Veglia Myeloid Cells in Glioblastoma Microenvironment Cells myeloid cells tumor-associated macrophages microglia neutrophils dendritic cells myeloid-derived suppressor cells |
| title | Myeloid Cells in Glioblastoma Microenvironment |
| title_full | Myeloid Cells in Glioblastoma Microenvironment |
| title_fullStr | Myeloid Cells in Glioblastoma Microenvironment |
| title_full_unstemmed | Myeloid Cells in Glioblastoma Microenvironment |
| title_short | Myeloid Cells in Glioblastoma Microenvironment |
| title_sort | myeloid cells in glioblastoma microenvironment |
| topic | myeloid cells tumor-associated macrophages microglia neutrophils dendritic cells myeloid-derived suppressor cells |
| url | https://www.mdpi.com/2073-4409/10/1/18 |
| work_keys_str_mv | AT alessandradeleo myeloidcellsinglioblastomamicroenvironment AT alessiougolini myeloidcellsinglioblastomamicroenvironment AT filippoveglia myeloidcellsinglioblastomamicroenvironment |