Dynamic frontotemporal systems process space and time in working memory.
How do we rapidly process incoming streams of information in working memory, a cognitive mechanism central to human behavior? Dominant views of working memory focus on the prefrontal cortex (PFC), but human hippocampal recordings provide a neurophysiological signature distinct from the PFC. Are thes...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-03-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC5895055?pdf=render |
| _version_ | 1818889376428457984 |
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| author | Elizabeth L Johnson Jenna N Adams Anne-Kristin Solbakk Tor Endestad Pål G Larsson Jugoslav Ivanovic Torstein R Meling Jack J Lin Robert T Knight |
| author_facet | Elizabeth L Johnson Jenna N Adams Anne-Kristin Solbakk Tor Endestad Pål G Larsson Jugoslav Ivanovic Torstein R Meling Jack J Lin Robert T Knight |
| author_sort | Elizabeth L Johnson |
| collection | DOAJ |
| description | How do we rapidly process incoming streams of information in working memory, a cognitive mechanism central to human behavior? Dominant views of working memory focus on the prefrontal cortex (PFC), but human hippocampal recordings provide a neurophysiological signature distinct from the PFC. Are these regions independent, or do they interact in the service of working memory? We addressed this core issue in behavior by recording directly from frontotemporal sites in humans performing a visuospatial working memory task that operationalizes the types of identity and spatiotemporal information we encounter every day. Theta band oscillations drove bidirectional interactions between the PFC and medial temporal lobe (MTL; including the hippocampus). MTL theta oscillations directed the PFC preferentially during the processing of spatiotemporal information, while PFC theta oscillations directed the MTL for all types of information being processed in working memory. These findings reveal an MTL theta mechanism for processing space and time and a domain-general PFC theta mechanism, providing evidence that rapid, dynamic MTL-PFC interactions underlie working memory for everyday experiences. |
| first_indexed | 2024-12-19T17:08:02Z |
| format | Article |
| id | doaj.art-82c307630de5477ab2d0139a5c7efc43 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-19T17:08:02Z |
| publishDate | 2018-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-82c307630de5477ab2d0139a5c7efc432022-12-21T20:13:06ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852018-03-01163e200427410.1371/journal.pbio.2004274Dynamic frontotemporal systems process space and time in working memory.Elizabeth L JohnsonJenna N AdamsAnne-Kristin SolbakkTor EndestadPål G LarssonJugoslav IvanovicTorstein R MelingJack J LinRobert T KnightHow do we rapidly process incoming streams of information in working memory, a cognitive mechanism central to human behavior? Dominant views of working memory focus on the prefrontal cortex (PFC), but human hippocampal recordings provide a neurophysiological signature distinct from the PFC. Are these regions independent, or do they interact in the service of working memory? We addressed this core issue in behavior by recording directly from frontotemporal sites in humans performing a visuospatial working memory task that operationalizes the types of identity and spatiotemporal information we encounter every day. Theta band oscillations drove bidirectional interactions between the PFC and medial temporal lobe (MTL; including the hippocampus). MTL theta oscillations directed the PFC preferentially during the processing of spatiotemporal information, while PFC theta oscillations directed the MTL for all types of information being processed in working memory. These findings reveal an MTL theta mechanism for processing space and time and a domain-general PFC theta mechanism, providing evidence that rapid, dynamic MTL-PFC interactions underlie working memory for everyday experiences.http://europepmc.org/articles/PMC5895055?pdf=render |
| spellingShingle | Elizabeth L Johnson Jenna N Adams Anne-Kristin Solbakk Tor Endestad Pål G Larsson Jugoslav Ivanovic Torstein R Meling Jack J Lin Robert T Knight Dynamic frontotemporal systems process space and time in working memory. PLoS Biology |
| title | Dynamic frontotemporal systems process space and time in working memory. |
| title_full | Dynamic frontotemporal systems process space and time in working memory. |
| title_fullStr | Dynamic frontotemporal systems process space and time in working memory. |
| title_full_unstemmed | Dynamic frontotemporal systems process space and time in working memory. |
| title_short | Dynamic frontotemporal systems process space and time in working memory. |
| title_sort | dynamic frontotemporal systems process space and time in working memory |
| url | http://europepmc.org/articles/PMC5895055?pdf=render |
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