MRI and PET/CT in the assessment of lymph node metastases in head and neck cancer
Abstract The aim of this study is to present the diagnostic accuracy of MRI and PET/CT in the evaluation of cervical lymph nodes in patients with head and neck cancer (HNC). Data of 114 patients who underwent MRI and PET/CT prior to surgery in the time period between January 2010 and September 2021...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-46845-y |
| _version_ | 1797630318084096000 |
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| author | Paul Zwittag Christian Asel Michael Gabriel Nina Rubicz Belinda Bauer Nikolaus Poier-Fabian |
| author_facet | Paul Zwittag Christian Asel Michael Gabriel Nina Rubicz Belinda Bauer Nikolaus Poier-Fabian |
| author_sort | Paul Zwittag |
| collection | DOAJ |
| description | Abstract The aim of this study is to present the diagnostic accuracy of MRI and PET/CT in the evaluation of cervical lymph nodes in patients with head and neck cancer (HNC). Data of 114 patients who underwent MRI and PET/CT prior to surgery in the time period between January 2010 and September 2021 in our center is analyzed retrospectively. Histopathological results of surgical preparations serve as the gold standard. The mean time from MRI to surgery is 22.9 (± 18.7) days, and from PET/CT to surgery 21.7 (± 19.9) days. Sensitivities of 80.4% and 80.4%, specificities of 85.7% and 87.3%, PPVs of 82.0% and 83.7% and NPVs of 84.4% and 84.6% are registered for MRI and PET/CT, respectively. 37 false results are further analyzed with respect to side and level of the affected lymph node, as well as intersections of the two imaging modalities. In 29 patients (25.4%), additional findings are described in PET/CT, 7 (6.1%) of which were histologically confirmed to be further malignancies. A combination of both MRI and PET/CT imaging modalities could improve diagnostic accuracy, especially with regard to sensitivity. A notable number of additional findings in whole body acquisition leads to the potential diagnosis of further malignancies. |
| first_indexed | 2024-03-11T11:05:29Z |
| format | Article |
| id | doaj.art-82c4936a9b9a4a68825f0766b3fd6fb4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-11T11:05:29Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-82c4936a9b9a4a68825f0766b3fd6fb42023-11-12T12:13:24ZengNature PortfolioScientific Reports2045-23222023-11-0113111010.1038/s41598-023-46845-yMRI and PET/CT in the assessment of lymph node metastases in head and neck cancerPaul Zwittag0Christian Asel1Michael Gabriel2Nina Rubicz3Belinda Bauer4Nikolaus Poier-Fabian5Department of Otorhinolaryngology, Head and Neck Surgery, Kepler University Hospital GmbHDepartment of Radiology, Kepler University Hospital GmbHInstitute of Nuclear Medicine and Endocrinology, Kepler University Hospital GmbHDepartment of Otorhinolaryngology, Head and Neck Surgery, Kepler University Hospital GmbHDepartment of Otorhinolaryngology, Head and Neck Surgery, Kepler University Hospital GmbHDepartment of Otorhinolaryngology, Head and Neck Surgery, Kepler University Hospital GmbHAbstract The aim of this study is to present the diagnostic accuracy of MRI and PET/CT in the evaluation of cervical lymph nodes in patients with head and neck cancer (HNC). Data of 114 patients who underwent MRI and PET/CT prior to surgery in the time period between January 2010 and September 2021 in our center is analyzed retrospectively. Histopathological results of surgical preparations serve as the gold standard. The mean time from MRI to surgery is 22.9 (± 18.7) days, and from PET/CT to surgery 21.7 (± 19.9) days. Sensitivities of 80.4% and 80.4%, specificities of 85.7% and 87.3%, PPVs of 82.0% and 83.7% and NPVs of 84.4% and 84.6% are registered for MRI and PET/CT, respectively. 37 false results are further analyzed with respect to side and level of the affected lymph node, as well as intersections of the two imaging modalities. In 29 patients (25.4%), additional findings are described in PET/CT, 7 (6.1%) of which were histologically confirmed to be further malignancies. A combination of both MRI and PET/CT imaging modalities could improve diagnostic accuracy, especially with regard to sensitivity. A notable number of additional findings in whole body acquisition leads to the potential diagnosis of further malignancies.https://doi.org/10.1038/s41598-023-46845-y |
| spellingShingle | Paul Zwittag Christian Asel Michael Gabriel Nina Rubicz Belinda Bauer Nikolaus Poier-Fabian MRI and PET/CT in the assessment of lymph node metastases in head and neck cancer Scientific Reports |
| title | MRI and PET/CT in the assessment of lymph node metastases in head and neck cancer |
| title_full | MRI and PET/CT in the assessment of lymph node metastases in head and neck cancer |
| title_fullStr | MRI and PET/CT in the assessment of lymph node metastases in head and neck cancer |
| title_full_unstemmed | MRI and PET/CT in the assessment of lymph node metastases in head and neck cancer |
| title_short | MRI and PET/CT in the assessment of lymph node metastases in head and neck cancer |
| title_sort | mri and pet ct in the assessment of lymph node metastases in head and neck cancer |
| url | https://doi.org/10.1038/s41598-023-46845-y |
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