PLK1 Activation in Late G2 Sets Up Commitment to Mitosis

PLK1 Activation in Late G2 Sets Up Commitment to Mitosis

Commitment to mitosis must be tightly coordinated with DNA replication to preserve genome integrity. While we have previously established that the timely activation of CyclinB1-Cdk1 in late G2 triggers mitotic entry, the upstream regulatory mechanisms remain unclear. Here, we report that Polo-like k...

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Bibliographic Details
Main Authors: Lilia Gheghiani, Damarys Loew, Bérangère Lombard, Jörg Mansfeld, Olivier Gavet
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
mitosis
G2 phase
Plk1
CyclinA2
Cdc25C
FRET biosensor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306733

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