Risk factor for steatorrhea in pediatric chronic pancreatitis patients
Abstract Background Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history o...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12876-018-0902-z |
| _version_ | 1818482826150936576 |
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| author | Lu Hao Teng Wang Lin He Ya-Wei Bi Di Zhang Xiang-Peng Zeng Lei Xin Jun Pan Dan Wang Jun-Tao Ji Ting-Ting Du Jin-Huan Lin Li-Sheng Wang Wen-Bin Zou Hui Chen Ting Xie Hong-Lei Guo Bai-Rong Li Zhuan Liao Zheng-Lei Xu Zhao-Shen Li Liang-Hao Hu |
| author_facet | Lu Hao Teng Wang Lin He Ya-Wei Bi Di Zhang Xiang-Peng Zeng Lei Xin Jun Pan Dan Wang Jun-Tao Ji Ting-Ting Du Jin-Huan Lin Li-Sheng Wang Wen-Bin Zou Hui Chen Ting Xie Hong-Lei Guo Bai-Rong Li Zhuan Liao Zheng-Lei Xu Zhao-Shen Li Liang-Hao Hu |
| author_sort | Lu Hao |
| collection | DOAJ |
| description | Abstract Background Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history of steatorrhea in CP. Methods CP patients admitted to our center from January 2000 to December 2013 were enrolled. Patients were assigned to the pediatric (< 18 years old) and adult group according to their age at onset of CP. Cumulative rates of steatorrhea in both groups were calculated. Risk factors for both groups were identified, respectively. Results The median follow-up duration for the whole cohort was 7.6 years. In a total of 2153 patients, 13.5% of them were pediatrics. The mean age at the onset and the diagnosis of CP in pediatrics were 11.622 and 19.727, respectively. Steatorrhea was detected in 46 patients (46/291, 15.8%) in the pediatric group and in 447 patients (447/1862, 24.0%) in the adult group. Age at the onset of CP (hazard ratio [HR], 1.121), diabetes mellitus (DM, HR, 51.140), and severe acute pancreatitis (SAP, HR, 13.946) was identified risk factor for steatorrhea in the pediatric group. Conclusions Age at the onset of CP, DM and SAP were identified risk factors for the development of steatorrhea in pediatric CP patients. The high-risk populations were suggested to be followed up closely. They may benefit from a full adequate pancreatic exocrine replacement therapy. |
| first_indexed | 2024-12-10T11:51:49Z |
| format | Article |
| id | doaj.art-82c52c13f000406cbf95daefee341e00 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-10T11:51:49Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-82c52c13f000406cbf95daefee341e002022-12-22T01:49:55ZengBMCBMC Gastroenterology1471-230X2018-12-0118111110.1186/s12876-018-0902-zRisk factor for steatorrhea in pediatric chronic pancreatitis patientsLu Hao0Teng Wang1Lin He2Ya-Wei Bi3Di Zhang4Xiang-Peng Zeng5Lei Xin6Jun Pan7Dan Wang8Jun-Tao Ji9Ting-Ting Du10Jin-Huan Lin11Li-Sheng Wang12Wen-Bin Zou13Hui Chen14Ting Xie15Hong-Lei Guo16Bai-Rong Li17Zhuan Liao18Zheng-Lei Xu19Zhao-Shen Li20Liang-Hao Hu21Department of Gastroenterology, Hainan Branch of Chinese PLA General HospitalDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Changhai Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, The Second Clinical Medical College (Shenzhen People’s Hospital), Jinan UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Zhongda Hospital, Southeast UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Air Force General HospitalDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, The Second Clinical Medical College (Shenzhen People’s Hospital), Jinan UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityDepartment of Gastroenterology, Gongli Hospital, The Second Military Medical UniversityAbstract Background Pediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history of steatorrhea in CP. Methods CP patients admitted to our center from January 2000 to December 2013 were enrolled. Patients were assigned to the pediatric (< 18 years old) and adult group according to their age at onset of CP. Cumulative rates of steatorrhea in both groups were calculated. Risk factors for both groups were identified, respectively. Results The median follow-up duration for the whole cohort was 7.6 years. In a total of 2153 patients, 13.5% of them were pediatrics. The mean age at the onset and the diagnosis of CP in pediatrics were 11.622 and 19.727, respectively. Steatorrhea was detected in 46 patients (46/291, 15.8%) in the pediatric group and in 447 patients (447/1862, 24.0%) in the adult group. Age at the onset of CP (hazard ratio [HR], 1.121), diabetes mellitus (DM, HR, 51.140), and severe acute pancreatitis (SAP, HR, 13.946) was identified risk factor for steatorrhea in the pediatric group. Conclusions Age at the onset of CP, DM and SAP were identified risk factors for the development of steatorrhea in pediatric CP patients. The high-risk populations were suggested to be followed up closely. They may benefit from a full adequate pancreatic exocrine replacement therapy.http://link.springer.com/article/10.1186/s12876-018-0902-zChronic pancreatitisPediatricSteatorrheaRisk factors |
| spellingShingle | Lu Hao Teng Wang Lin He Ya-Wei Bi Di Zhang Xiang-Peng Zeng Lei Xin Jun Pan Dan Wang Jun-Tao Ji Ting-Ting Du Jin-Huan Lin Li-Sheng Wang Wen-Bin Zou Hui Chen Ting Xie Hong-Lei Guo Bai-Rong Li Zhuan Liao Zheng-Lei Xu Zhao-Shen Li Liang-Hao Hu Risk factor for steatorrhea in pediatric chronic pancreatitis patients BMC Gastroenterology Chronic pancreatitis Pediatric Steatorrhea Risk factors |
| title | Risk factor for steatorrhea in pediatric chronic pancreatitis patients |
| title_full | Risk factor for steatorrhea in pediatric chronic pancreatitis patients |
| title_fullStr | Risk factor for steatorrhea in pediatric chronic pancreatitis patients |
| title_full_unstemmed | Risk factor for steatorrhea in pediatric chronic pancreatitis patients |
| title_short | Risk factor for steatorrhea in pediatric chronic pancreatitis patients |
| title_sort | risk factor for steatorrhea in pediatric chronic pancreatitis patients |
| topic | Chronic pancreatitis Pediatric Steatorrhea Risk factors |
| url | http://link.springer.com/article/10.1186/s12876-018-0902-z |
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