Microbiota-induced regulatory T cells associate with FUT2-dependent susceptibility to rotavirus gastroenteritis

Microbiota-induced regulatory T cells associate with FUT2-dependent susceptibility to rotavirus gastroenteritis

The FUT2 α1,2fucosyltransferase contributes to the synthesis of fucosylated glycans used as attachment factors by several pathogens, including noroviruses and rotaviruses, that can induce life-threatening gastroenteritis in young children. FUT2 genetic polymorphisms impairing fucosylation are strong...

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Bibliographic Details
Main Authors: Emmanuelle Godefroy, Laure Barbé, Béatrice Le Moullac-Vaidye, Jézabel Rocher, Adrien Breiman, Sébastien Leuillet, Denis Mariat, Jean-Marc Chatel, Nathalie Ruvoën-Clouet, Thomas Carton, Francine Jotereau, Jacques Le Pendu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Microbiology
Subjects:
inflammatory diseases
FUT2
fucosylation
histo-blood group antigens
rotavirus
antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1123803/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1123803/full

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