Anesthesia and analgesia for common research models of adult mice
Abstract Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles. In many cases, it seems “anesthesia” and “analgesia” are...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Laboratory Animal Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42826-022-00150-3 |
| _version_ | 1798005072347529216 |
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| author | Siavash Ahmadi-Noorbakhsh Mohammad Farajli Abbasi Maedeh Ghasemi Gholamreza Bayat Nahid Davoodian Ehsan Sharif-Paghaleh Seyedeh Mahsa Poormoosavi Melika Rafizadeh Maryam Maleki Hesamaddin Shirzad-Aski Hossein Kargar Jahromi Masoomeh Dadkhah Bahman Khalvati Tahereh Safari Mohammad Amin Behmanesh Seyed Esmaeil Khoshnam Gholamreza Houshmand Sayyed Alireza Talaei |
| author_facet | Siavash Ahmadi-Noorbakhsh Mohammad Farajli Abbasi Maedeh Ghasemi Gholamreza Bayat Nahid Davoodian Ehsan Sharif-Paghaleh Seyedeh Mahsa Poormoosavi Melika Rafizadeh Maryam Maleki Hesamaddin Shirzad-Aski Hossein Kargar Jahromi Masoomeh Dadkhah Bahman Khalvati Tahereh Safari Mohammad Amin Behmanesh Seyed Esmaeil Khoshnam Gholamreza Houshmand Sayyed Alireza Talaei |
| author_sort | Siavash Ahmadi-Noorbakhsh |
| collection | DOAJ |
| description | Abstract Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles. In many cases, it seems “anesthesia” and “analgesia” are used interchangeably, while they are referring to two different concepts. Not only this is an unethical practice, but also it may be one of the reasons for the proven suboptimal quality of many animal researches. This is a widespread problem among investigations on various species of animals. However, it could be imagined that it may be more prevalent for the most common species of laboratory animals, such as the laboratory mice. In this review, proper anesthetic/analgesic methods for routine procedures on laboratory mice are discussed. We considered the available literature and critically reviewed their anesthetic/analgesic methods. Detailed dosing and pharmacological information for the relevant drugs are provided and some of the drugs’ side effects are discussed. This paper provides the necessary data for an informed choice of anesthetic/analgesic methods in some routine procedures on laboratory mice. |
| first_indexed | 2024-04-11T12:33:31Z |
| format | Article |
| id | doaj.art-82ca2151f72a4c34a831a1145e941f82 |
| institution | Directory Open Access Journal |
| issn | 2233-7660 |
| language | English |
| last_indexed | 2024-04-11T12:33:31Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Laboratory Animal Research |
| spelling | doaj.art-82ca2151f72a4c34a831a1145e941f822022-12-22T04:23:41ZengBMCLaboratory Animal Research2233-76602022-12-0138111610.1186/s42826-022-00150-3Anesthesia and analgesia for common research models of adult miceSiavash Ahmadi-Noorbakhsh0Mohammad Farajli Abbasi1Maedeh Ghasemi2Gholamreza Bayat3Nahid Davoodian4Ehsan Sharif-Paghaleh5Seyedeh Mahsa Poormoosavi6Melika Rafizadeh7Maryam Maleki8Hesamaddin Shirzad-Aski9Hossein Kargar Jahromi10Masoomeh Dadkhah11Bahman Khalvati12Tahereh Safari13Mohammad Amin Behmanesh14Seyed Esmaeil Khoshnam15Gholamreza Houshmand16Sayyed Alireza Talaei17Preclinical Core Facility (TPCF), Tehran University of Medical SciencesNeuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical SciencesDepartment of Physiology, School of Medicine, Isfahan University of Medical SciencesDepartment of Physiology-Pharmacology-Medical Physic, School of Medicine, Alborz University of Medical SciencesEndocrinology and Metabolism Research Center, Hormozgan University of Medical SciencesPreclinical Core Facility (TPCF), Tehran University of Medical SciencesDepartment of Histology, School of Medicine, Research and Clinical Center for Infertility, Dezful University of Medical SciencesDepartment of Pharmacology, Medical School, Shahid Beheshti University of Medical SciencesDepartment of Physiology, Faculty of Medicine, Ilam University of Medical SciencesInfectious Diseases Research Center, Golestan University of Medical SciencesResearch Center for Non-Communicable Disease, Jahrom University of Medical SciencesPharmaceutical Sciences Research Center, Ardabil University of Medical SciencesMedicinal Plants Research Center, Yasuj University of Medical SciencesSchool of Medicine, Department of Physiology, PhD, Zahedan University of Medical SciencesDepartment of Histology, School of Medicine, Dezful University of Medical SciencesMedical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical SciencesPsychiatry and Behavioral Sciences Research Center, Addiction Institute, Department of Pharmacology, Faculty of Medicine, Mazandaran University of Medical SciencesPhysiology Research Center, Institute for Basic Sciences, Kashan University of Medical SciencesAbstract Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles. In many cases, it seems “anesthesia” and “analgesia” are used interchangeably, while they are referring to two different concepts. Not only this is an unethical practice, but also it may be one of the reasons for the proven suboptimal quality of many animal researches. This is a widespread problem among investigations on various species of animals. However, it could be imagined that it may be more prevalent for the most common species of laboratory animals, such as the laboratory mice. In this review, proper anesthetic/analgesic methods for routine procedures on laboratory mice are discussed. We considered the available literature and critically reviewed their anesthetic/analgesic methods. Detailed dosing and pharmacological information for the relevant drugs are provided and some of the drugs’ side effects are discussed. This paper provides the necessary data for an informed choice of anesthetic/analgesic methods in some routine procedures on laboratory mice.https://doi.org/10.1186/s42826-022-00150-3AnestheticAnalgesicMousePharmacologySide effectPreclinical |
| spellingShingle | Siavash Ahmadi-Noorbakhsh Mohammad Farajli Abbasi Maedeh Ghasemi Gholamreza Bayat Nahid Davoodian Ehsan Sharif-Paghaleh Seyedeh Mahsa Poormoosavi Melika Rafizadeh Maryam Maleki Hesamaddin Shirzad-Aski Hossein Kargar Jahromi Masoomeh Dadkhah Bahman Khalvati Tahereh Safari Mohammad Amin Behmanesh Seyed Esmaeil Khoshnam Gholamreza Houshmand Sayyed Alireza Talaei Anesthesia and analgesia for common research models of adult mice Laboratory Animal Research Anesthetic Analgesic Mouse Pharmacology Side effect Preclinical |
| title | Anesthesia and analgesia for common research models of adult mice |
| title_full | Anesthesia and analgesia for common research models of adult mice |
| title_fullStr | Anesthesia and analgesia for common research models of adult mice |
| title_full_unstemmed | Anesthesia and analgesia for common research models of adult mice |
| title_short | Anesthesia and analgesia for common research models of adult mice |
| title_sort | anesthesia and analgesia for common research models of adult mice |
| topic | Anesthetic Analgesic Mouse Pharmacology Side effect Preclinical |
| url | https://doi.org/10.1186/s42826-022-00150-3 |
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