Autoimmunity in thymic epithelial tumors: a not yet clarified pathologic paradigm associated with several unmet clinical needs

Autoimmunity in thymic epithelial tumors: a not yet clarified pathologic paradigm associated with several unmet clinical needs

Thymic epithelial tumors (TETs) are rare mediastinal cancers originating from the thymus, classified in two main histotypes: thymoma and thymic carcinoma (TC). TETs affect a primary lymphoid organ playing a critical role in keeping T-cell homeostasis and ensuring an adequate immunological tolerance...

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Main Authors: Matteo Perrino, Emanuele Voulaz, Simone Balin, Gerardo Cazzato, Elena Fontana, Sara Franzese, Martina Defendi, Fabio De Vincenzo, Nadia Cordua, Roberto Tamma, Federica Borea, Marta Aliprandi, Marco Airoldi, Luigi Giovanni Cecchi, Roberta Fazio, Marco Alloisio, Giuseppe Marulli, Armando Santoro, Luca Di Tommaso, Giuseppe Ingravallo, Laura Russo, Giorgio Da Rin, Anna Villa, Silvia Della Bella, Paolo Andrea Zucali, Domenico Mavilio
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
thymic epithelial tumors
autoimmunity
myasthenia gravis
immunotherapy
surgery
thymopoiesis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1288045/full

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