Norcantharidin Sensitizes Colorectal Cancer Cells to Radiotherapy via Reactive Oxygen Species–DRP1-Mediated Mitochondrial Damage

Norcantharidin Sensitizes Colorectal Cancer Cells to Radiotherapy via Reactive Oxygen Species–DRP1-Mediated Mitochondrial Damage

Norcantharidin (NCTD), a cantharidin derivative, induces ROS generation and is widely used to treat CRC. In this study, we clarified the role and mechanism of action of norcantharidin in increasing CRC sensitivity to radiotherapy. We treated the CRC cell lines LoVo and DLD-1 with NCTD (10 or 50 μmol...

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Bibliographic Details
Main Authors: Qiong Xu, Heng Zhang, Haoren Qin, Huaqing Wang, Hui Wang
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Antioxidants
Subjects:
ROS
NCTD
colorectal cancer
mitochondria
DRP1
Online Access:https://www.mdpi.com/2076-3921/13/3/347

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