Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian Metamorphosis
Nitric oxide (NO) is a pivotal signaling molecule involved in a wide range of physiological and pathological processes. We investigated NOS/NO localization patterns during the different stages of larval development in the ascidia <i>Ciona robusta</i> and evidenced a specific and temporal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/7/3505 |
| _version_ | 1797439150097432576 |
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| author | Annamaria Locascio Quirino Attilio Vassalli Immacolata Castellano Anna Palumbo |
| author_facet | Annamaria Locascio Quirino Attilio Vassalli Immacolata Castellano Anna Palumbo |
| author_sort | Annamaria Locascio |
| collection | DOAJ |
| description | Nitric oxide (NO) is a pivotal signaling molecule involved in a wide range of physiological and pathological processes. We investigated NOS/NO localization patterns during the different stages of larval development in the ascidia <i>Ciona robusta</i> and evidenced a specific and temporally controlled pattern. NOS/NO expression starts in the most anterior sensory structures of the early larva and progressively moves towards the caudal portion as larval development and metamorphosis proceeds. We here highlight the pattern of NOS/NO expression in the central and peripheral nervous system of <i>Ciona</i> larvae which precisely follows the progression of neural signals of the central pattern generator necessary for the control of the movements of the larva towards the substrate. This highly dynamic localization profile perfectly matches with the central role played by NO from the first phase of settlement induction to the next control of swimming behavior, adhesion to substrate and progressive tissue resorption and reorganization of metamorphosis itself. |
| first_indexed | 2024-03-09T11:48:32Z |
| format | Article |
| id | doaj.art-82cb224187eb4928bcb282d7a89e71fc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T11:48:32Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-82cb224187eb4928bcb282d7a89e71fc2023-11-30T23:17:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01237350510.3390/ijms23073505Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian MetamorphosisAnnamaria Locascio0Quirino Attilio Vassalli1Immacolata Castellano2Anna Palumbo3Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, ItalyDepartment of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, ItalyDepartment of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, ItalyDepartment of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Napoli, ItalyNitric oxide (NO) is a pivotal signaling molecule involved in a wide range of physiological and pathological processes. We investigated NOS/NO localization patterns during the different stages of larval development in the ascidia <i>Ciona robusta</i> and evidenced a specific and temporally controlled pattern. NOS/NO expression starts in the most anterior sensory structures of the early larva and progressively moves towards the caudal portion as larval development and metamorphosis proceeds. We here highlight the pattern of NOS/NO expression in the central and peripheral nervous system of <i>Ciona</i> larvae which precisely follows the progression of neural signals of the central pattern generator necessary for the control of the movements of the larva towards the substrate. This highly dynamic localization profile perfectly matches with the central role played by NO from the first phase of settlement induction to the next control of swimming behavior, adhesion to substrate and progressive tissue resorption and reorganization of metamorphosis itself.https://www.mdpi.com/1422-0067/23/7/3505<i>Ciona robusta</i>nitric oxide synthaseNO signalingtail regressionlarval developmentswimming |
| spellingShingle | Annamaria Locascio Quirino Attilio Vassalli Immacolata Castellano Anna Palumbo Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian Metamorphosis International Journal of Molecular Sciences <i>Ciona robusta</i> nitric oxide synthase NO signaling tail regression larval development swimming |
| title | Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian Metamorphosis |
| title_full | Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian Metamorphosis |
| title_fullStr | Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian Metamorphosis |
| title_full_unstemmed | Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian Metamorphosis |
| title_short | Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian Metamorphosis |
| title_sort | novel insights on nitric oxide synthase and no signaling in ascidian metamorphosis |
| topic | <i>Ciona robusta</i> nitric oxide synthase NO signaling tail regression larval development swimming |
| url | https://www.mdpi.com/1422-0067/23/7/3505 |
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