The impact of visit‐to‐visit heart rate variability on all‐cause mortality in atrial fibrillation
Abstract Objective We aimed to investigate the association between visit‐to‐visit heart rate variability (VVHRV) and all‐cause mortality in patients diagnosed with atrial fibrillation (AF). Previous studies have shown a positive correlation between VVHRV and several adverse outcomes. However, the re...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Annals of Noninvasive Electrocardiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/anec.13094 |
| _version_ | 1797338759187922944 |
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| author | Xiaoyan Zhou Qinghua Yuan Jie Yuan Zhi‐Min Du Xiaodong Zhuang Xinxue Liao |
| author_facet | Xiaoyan Zhou Qinghua Yuan Jie Yuan Zhi‐Min Du Xiaodong Zhuang Xinxue Liao |
| author_sort | Xiaoyan Zhou |
| collection | DOAJ |
| description | Abstract Objective We aimed to investigate the association between visit‐to‐visit heart rate variability (VVHRV) and all‐cause mortality in patients diagnosed with atrial fibrillation (AF). Previous studies have shown a positive correlation between VVHRV and several adverse outcomes. However, the relationship between VVHRV and the prognosis of AF remains uncertain. Methods In our study, we aimed to examine the relationship between VVHRV and mortality rates among 3983 participants with AF, who were part of the AFFIRM study (Atrial Fibrillation Follow‐Up Investigation of Rhythm Management). We used the standard deviation of heart rate (HRSD) to measure VVHRV and divided the patients into four groups based on quartiles of HRSD (1st, <5.69; 2nd, 5.69–8.00; 3rd, 8.01–11.01; and 4th, ≥11.02). Our primary endpoint was all‐cause death, and we estimated the hazard ratios for mortality using the Cox proportional hazard regressions. Results Our analysis included 3983 participants from the AFFIRM study and followed for an average of 3.5 years. During this period, 621 participants died from all causes. In multiple‐adjustment models, we found that the lowest and highest quartiles of HRSD independently predicted an increased risk of all‐cause mortality compared to the other two quartiles, presenting a U‐shaped relationship (1st vs 2nd, hazard ratio = 2.28, 95% CI = 1.63–3.20, p < .01; 1st vs. 3rd, hazard ratio = 2.23, 95% CI = 1.60–3.11, p < .01; 4th vs. 2nd, hazard ratio = 1.82, 95% CI = 1.26–2.61, p < .01; and 4th vs. 3rd, hazard ratio = 1.78, 95% CI = 1.25–2.52, p < .01). Conclusion In patients with AF, we found that both lower VVHRV and higher VVHRV increased the risk of all‐cause mortality, indicating a U‐shaped curve relationship. |
| first_indexed | 2024-03-08T09:35:56Z |
| format | Article |
| id | doaj.art-82cbfcc9773840ffafea1eb02df2099e |
| institution | Directory Open Access Journal |
| issn | 1082-720X 1542-474X |
| language | English |
| last_indexed | 2024-03-08T09:35:56Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Noninvasive Electrocardiology |
| spelling | doaj.art-82cbfcc9773840ffafea1eb02df2099e2024-01-30T08:36:49ZengWileyAnnals of Noninvasive Electrocardiology1082-720X1542-474X2024-01-01291n/an/a10.1111/anec.13094The impact of visit‐to‐visit heart rate variability on all‐cause mortality in atrial fibrillationXiaoyan Zhou0Qinghua Yuan1Jie Yuan2Zhi‐Min Du3Xiaodong Zhuang4Xinxue Liao5Department of Cardiology The Seventh Affiliated Hospital of SunYat‐sen University Shenzhen ChinaDepartment of Cardiology The Seventh Affiliated Hospital of SunYat‐sen University Shenzhen ChinaHanyi Data Technology (Shenzhen) Co., Ltd Shenzhen ChinaDepartment of Cardiology The Seventh Affiliated Hospital of SunYat‐sen University Shenzhen ChinaDepartment of Cardiology, The First Affiliated Hospital Sun Yat‐sen University Guangzhou ChinaDepartment of Cardiology, The First Affiliated Hospital Sun Yat‐sen University Guangzhou ChinaAbstract Objective We aimed to investigate the association between visit‐to‐visit heart rate variability (VVHRV) and all‐cause mortality in patients diagnosed with atrial fibrillation (AF). Previous studies have shown a positive correlation between VVHRV and several adverse outcomes. However, the relationship between VVHRV and the prognosis of AF remains uncertain. Methods In our study, we aimed to examine the relationship between VVHRV and mortality rates among 3983 participants with AF, who were part of the AFFIRM study (Atrial Fibrillation Follow‐Up Investigation of Rhythm Management). We used the standard deviation of heart rate (HRSD) to measure VVHRV and divided the patients into four groups based on quartiles of HRSD (1st, <5.69; 2nd, 5.69–8.00; 3rd, 8.01–11.01; and 4th, ≥11.02). Our primary endpoint was all‐cause death, and we estimated the hazard ratios for mortality using the Cox proportional hazard regressions. Results Our analysis included 3983 participants from the AFFIRM study and followed for an average of 3.5 years. During this period, 621 participants died from all causes. In multiple‐adjustment models, we found that the lowest and highest quartiles of HRSD independently predicted an increased risk of all‐cause mortality compared to the other two quartiles, presenting a U‐shaped relationship (1st vs 2nd, hazard ratio = 2.28, 95% CI = 1.63–3.20, p < .01; 1st vs. 3rd, hazard ratio = 2.23, 95% CI = 1.60–3.11, p < .01; 4th vs. 2nd, hazard ratio = 1.82, 95% CI = 1.26–2.61, p < .01; and 4th vs. 3rd, hazard ratio = 1.78, 95% CI = 1.25–2.52, p < .01). Conclusion In patients with AF, we found that both lower VVHRV and higher VVHRV increased the risk of all‐cause mortality, indicating a U‐shaped curve relationship.https://doi.org/10.1111/anec.13094all‐cause mortalityatrial fibrillationvisit‐to‐visit heart rate variability |
| spellingShingle | Xiaoyan Zhou Qinghua Yuan Jie Yuan Zhi‐Min Du Xiaodong Zhuang Xinxue Liao The impact of visit‐to‐visit heart rate variability on all‐cause mortality in atrial fibrillation Annals of Noninvasive Electrocardiology all‐cause mortality atrial fibrillation visit‐to‐visit heart rate variability |
| title | The impact of visit‐to‐visit heart rate variability on all‐cause mortality in atrial fibrillation |
| title_full | The impact of visit‐to‐visit heart rate variability on all‐cause mortality in atrial fibrillation |
| title_fullStr | The impact of visit‐to‐visit heart rate variability on all‐cause mortality in atrial fibrillation |
| title_full_unstemmed | The impact of visit‐to‐visit heart rate variability on all‐cause mortality in atrial fibrillation |
| title_short | The impact of visit‐to‐visit heart rate variability on all‐cause mortality in atrial fibrillation |
| title_sort | impact of visit to visit heart rate variability on all cause mortality in atrial fibrillation |
| topic | all‐cause mortality atrial fibrillation visit‐to‐visit heart rate variability |
| url | https://doi.org/10.1111/anec.13094 |
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