Microvascular Function and Exercise Training: Functional Implication of Nitric Oxide Signaling and Ion Channels
Background: Exercise training elicits indubitable positive adaptation in microcirculation in health and disease populations. An inclusive overview of the current knowledge regarding the effects of exercise on microvascular function consolidates an in-depth understanding of microvasculature. Summary:...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2024-03-01
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| Series: | Pulse |
| Subjects: | |
| Online Access: | https://beta.karger.com/Article/FullText/538271 |
| _version_ | 1827287743314526208 |
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| author | Junyoung Hong Yoonjung Park |
| author_facet | Junyoung Hong Yoonjung Park |
| author_sort | Junyoung Hong |
| collection | DOAJ |
| description | Background: Exercise training elicits indubitable positive adaptation in microcirculation in health and disease populations. An inclusive overview of the current knowledge regarding the effects of exercise on microvascular function consolidates an in-depth understanding of microvasculature. Summary: The main physiological function of microvasculature is to maintain optimal blood flow regulation to supply oxygen and nutrition during elevated physical demands in the cardiovascular system. There are several cellular and molecular alterations in resistance vessels in response to exercise intervention, an increase in nitric oxide-mediated vasodilation through the regulation of oxidative stress, inflammatory response, and ion channels in endothelial cells, thus increasing myogenic tone via voltage-gated Ca2+ channels in smooth muscle cells. Key Messages: In the review, we postulate that exercise should be considered a medicine for people with diverse diseases through a comprehensive understanding of the cellular and molecular underlying mechanisms in microcirculation through exercise training. |
| first_indexed | 2024-04-24T11:17:14Z |
| format | Article |
| id | doaj.art-82cc3aab4fa94c12b6af61ca3e74fc32 |
| institution | Directory Open Access Journal |
| issn | 2235-8668 |
| language | English |
| last_indexed | 2024-04-24T11:17:14Z |
| publishDate | 2024-03-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Pulse |
| spelling | doaj.art-82cc3aab4fa94c12b6af61ca3e74fc322024-04-11T06:33:40ZengKarger PublishersPulse2235-86682024-03-01121273310.1159/000538271538271Microvascular Function and Exercise Training: Functional Implication of Nitric Oxide Signaling and Ion ChannelsJunyoung Hong0Yoonjung Park1Department of Health and Human Performance, Laboratory of Integrated Physiology, University of Houston, Houston, TX, USADepartment of Health and Human Performance, Laboratory of Integrated Physiology, University of Houston, Houston, TX, USABackground: Exercise training elicits indubitable positive adaptation in microcirculation in health and disease populations. An inclusive overview of the current knowledge regarding the effects of exercise on microvascular function consolidates an in-depth understanding of microvasculature. Summary: The main physiological function of microvasculature is to maintain optimal blood flow regulation to supply oxygen and nutrition during elevated physical demands in the cardiovascular system. There are several cellular and molecular alterations in resistance vessels in response to exercise intervention, an increase in nitric oxide-mediated vasodilation through the regulation of oxidative stress, inflammatory response, and ion channels in endothelial cells, thus increasing myogenic tone via voltage-gated Ca2+ channels in smooth muscle cells. Key Messages: In the review, we postulate that exercise should be considered a medicine for people with diverse diseases through a comprehensive understanding of the cellular and molecular underlying mechanisms in microcirculation through exercise training.https://beta.karger.com/Article/FullText/538271exercisenitric oxideion channelsmicrovascular functionvascular functionendothelial cellssmooth muscle cells |
| spellingShingle | Junyoung Hong Yoonjung Park Microvascular Function and Exercise Training: Functional Implication of Nitric Oxide Signaling and Ion Channels Pulse exercise nitric oxide ion channels microvascular function vascular function endothelial cells smooth muscle cells |
| title | Microvascular Function and Exercise Training: Functional Implication of Nitric Oxide Signaling and Ion Channels |
| title_full | Microvascular Function and Exercise Training: Functional Implication of Nitric Oxide Signaling and Ion Channels |
| title_fullStr | Microvascular Function and Exercise Training: Functional Implication of Nitric Oxide Signaling and Ion Channels |
| title_full_unstemmed | Microvascular Function and Exercise Training: Functional Implication of Nitric Oxide Signaling and Ion Channels |
| title_short | Microvascular Function and Exercise Training: Functional Implication of Nitric Oxide Signaling and Ion Channels |
| title_sort | microvascular function and exercise training functional implication of nitric oxide signaling and ion channels |
| topic | exercise nitric oxide ion channels microvascular function vascular function endothelial cells smooth muscle cells |
| url | https://beta.karger.com/Article/FullText/538271 |
| work_keys_str_mv | AT junyounghong microvascularfunctionandexercisetrainingfunctionalimplicationofnitricoxidesignalingandionchannels AT yoonjungpark microvascularfunctionandexercisetrainingfunctionalimplicationofnitricoxidesignalingandionchannels |