Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum

Cell-Type Specific Regulation of Cholesterogenesis by CYP46A1 Re-Expression in zQ175 HD Mouse Striatum

Cholesterol metabolism dysregulation is associated with several neurological disorders. In Huntington’s disease (HD), several enzymes involved in cholesterol metabolism are downregulated, among which the neuronal cholesterol 24-hydroxylase, CYP46A1, is of particular interest. The restoration of CYP4...

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Bibliographic Details
Main Authors:	Katleen Pinchaud, Chloé Masson, Baptiste Dayre, Coline Mounier, Jean-François Gilles, Peter Vanhoutte, Jocelyne Caboche, Sandrine Betuing
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Series:	International Journal of Molecular Sciences
Subjects:	Huntington’s disease striatum CYP46A1 cholesterol gene regulation <i>Srebp2</i>
Online Access:	https://www.mdpi.com/1422-0067/24/13/11001

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