A Novel Protocol for Gastric Lavage in Patients with Aluminum Phosphide Poisoning: A Double-Blind Study
Aluminum phosphide poisoning (ALPP) still has no efficient and approved antidote. Supportive care and hemodynamic monitoring are the only choices of treatment. We proposed a new lavage formulation in addition to evaluation of its efficacy and defining the impact of clinical characteristics of patien...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2012-08-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/3943 |
| _version_ | 1811267698596773888 |
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| author | Babak Mostafazadeh Esmaeil Farzaneh |
| author_facet | Babak Mostafazadeh Esmaeil Farzaneh |
| author_sort | Babak Mostafazadeh |
| collection | DOAJ |
| description | Aluminum phosphide poisoning (ALPP) still has no efficient and approved antidote. Supportive care and hemodynamic monitoring are the only choices of treatment. We proposed a new lavage formulation in addition to evaluation of its efficacy and defining the impact of clinical characteristics of patients on their prognosis. During eight months period of time, 120 patients were enrolled to the study and randomly received two different gastric lavage protocols. Our new lavage protocol had positive impact on patients' survival and the P-value in comparison with the classic gastric lavage method was close to significant level (P=0.054). On hospital arrival indication for intubation-ventilation as well as sense of thirst, sore throat and absence of nausea indicate worse outcome. Using our novel approach, indication for intubation-ventilation as well as sense of thirst, sore throat and absence of nausea can be considered as applicable prognostic factors in survival of ALPP patients. Further studies are required to set this approach as preferred treatment. |
| first_indexed | 2024-04-12T21:07:22Z |
| format | Article |
| id | doaj.art-82ce1e8248ea4ef9b30ea78f7d49f20d |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-04-12T21:07:22Z |
| publishDate | 2012-08-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-82ce1e8248ea4ef9b30ea78f7d49f20d2022-12-22T03:16:40ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942012-08-01508A Novel Protocol for Gastric Lavage in Patients with Aluminum Phosphide Poisoning: A Double-Blind StudyBabak Mostafazadeh0Esmaeil Farzaneh1Department of Forensic Medicine and Toxicology, Loghman Hakim Hospital Poison Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AND Toxicological Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Forensic Medicine and Toxicology, Ardabil University of Medical Sciences, Ardabil, Iran.Aluminum phosphide poisoning (ALPP) still has no efficient and approved antidote. Supportive care and hemodynamic monitoring are the only choices of treatment. We proposed a new lavage formulation in addition to evaluation of its efficacy and defining the impact of clinical characteristics of patients on their prognosis. During eight months period of time, 120 patients were enrolled to the study and randomly received two different gastric lavage protocols. Our new lavage protocol had positive impact on patients' survival and the P-value in comparison with the classic gastric lavage method was close to significant level (P=0.054). On hospital arrival indication for intubation-ventilation as well as sense of thirst, sore throat and absence of nausea indicate worse outcome. Using our novel approach, indication for intubation-ventilation as well as sense of thirst, sore throat and absence of nausea can be considered as applicable prognostic factors in survival of ALPP patients. Further studies are required to set this approach as preferred treatment.https://acta.tums.ac.ir/index.php/acta/article/view/3943Aluminum PhosphidePoisoningGastric lavageNovel treatment |
| spellingShingle | Babak Mostafazadeh Esmaeil Farzaneh A Novel Protocol for Gastric Lavage in Patients with Aluminum Phosphide Poisoning: A Double-Blind Study Acta Medica Iranica Aluminum Phosphide Poisoning Gastric lavage Novel treatment |
| title | A Novel Protocol for Gastric Lavage in Patients with Aluminum Phosphide Poisoning: A Double-Blind Study |
| title_full | A Novel Protocol for Gastric Lavage in Patients with Aluminum Phosphide Poisoning: A Double-Blind Study |
| title_fullStr | A Novel Protocol for Gastric Lavage in Patients with Aluminum Phosphide Poisoning: A Double-Blind Study |
| title_full_unstemmed | A Novel Protocol for Gastric Lavage in Patients with Aluminum Phosphide Poisoning: A Double-Blind Study |
| title_short | A Novel Protocol for Gastric Lavage in Patients with Aluminum Phosphide Poisoning: A Double-Blind Study |
| title_sort | novel protocol for gastric lavage in patients with aluminum phosphide poisoning a double blind study |
| topic | Aluminum Phosphide Poisoning Gastric lavage Novel treatment |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/3943 |
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