Pregnant women carrying female fetuses are at higher risk of placental malaria infection.
The pathophysiology of the placental malaria is not fully understood. If there is a fetal sex-specific susceptibility to malaria infection, this might add to the previous knowledge on the immunology, endocrinology and pathophysiology of placental malaria infections.This study was conducted to assess...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5533337?pdf=render |
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| author | Ishag Adam Magdi M Salih Ahmed A Mohmmed Duria A Rayis Mustafa I Elbashir |
| author_facet | Ishag Adam Magdi M Salih Ahmed A Mohmmed Duria A Rayis Mustafa I Elbashir |
| author_sort | Ishag Adam |
| collection | DOAJ |
| description | The pathophysiology of the placental malaria is not fully understood. If there is a fetal sex-specific susceptibility to malaria infection, this might add to the previous knowledge on the immunology, endocrinology and pathophysiology of placental malaria infections.This study was conducted to assess whether the sex of the fetus was associated with placental malaria infections.A cross-sectional study was performed including a secondary analysis of a cohort of women who were investigated for prevalence and risk factors (including fetal sex) for placental malaria in eastern Sudan. Placental histology was used to diagnose placental malaria infections.Among 339 women enrolled, the mean (SD) age was 25.8 (6.7) years and parity was 2.7 (2.2). Among the new born babies, 157 (46.3%) were male and 182 (53.7%) were female. Five (1.5%), 9 (2.7%) and 103 (30.4%) of the 339 placentas had active, active-chronic, past-chronic malaria infection on histopathology examination respectively, while 222 (65.5%) of them showed no malaria infection. Logistic regression analyses showed no associations between maternal age or parity and placental malaria infections. Women who have blood group O (OR = 1.95, 95% CI = 1.19-3.10; P = 0.007) and women who had female new born were at higher risk for placental malaria infections (OR = 2.55, 95% CI = 1.57-4.13; P< 0.001).Fetal gender may be a novel risk factor for placental malaria. In this work the female placentas were at higher risk for malaria infections than the male placentas. |
| first_indexed | 2024-12-14T20:53:06Z |
| format | Article |
| id | doaj.art-82cefcb2fb644530b7d449358acaa972 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T20:53:06Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-82cefcb2fb644530b7d449358acaa9722022-12-21T22:47:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01127e018239410.1371/journal.pone.0182394Pregnant women carrying female fetuses are at higher risk of placental malaria infection.Ishag AdamMagdi M SalihAhmed A MohmmedDuria A RayisMustafa I ElbashirThe pathophysiology of the placental malaria is not fully understood. If there is a fetal sex-specific susceptibility to malaria infection, this might add to the previous knowledge on the immunology, endocrinology and pathophysiology of placental malaria infections.This study was conducted to assess whether the sex of the fetus was associated with placental malaria infections.A cross-sectional study was performed including a secondary analysis of a cohort of women who were investigated for prevalence and risk factors (including fetal sex) for placental malaria in eastern Sudan. Placental histology was used to diagnose placental malaria infections.Among 339 women enrolled, the mean (SD) age was 25.8 (6.7) years and parity was 2.7 (2.2). Among the new born babies, 157 (46.3%) were male and 182 (53.7%) were female. Five (1.5%), 9 (2.7%) and 103 (30.4%) of the 339 placentas had active, active-chronic, past-chronic malaria infection on histopathology examination respectively, while 222 (65.5%) of them showed no malaria infection. Logistic regression analyses showed no associations between maternal age or parity and placental malaria infections. Women who have blood group O (OR = 1.95, 95% CI = 1.19-3.10; P = 0.007) and women who had female new born were at higher risk for placental malaria infections (OR = 2.55, 95% CI = 1.57-4.13; P< 0.001).Fetal gender may be a novel risk factor for placental malaria. In this work the female placentas were at higher risk for malaria infections than the male placentas.http://europepmc.org/articles/PMC5533337?pdf=render |
| spellingShingle | Ishag Adam Magdi M Salih Ahmed A Mohmmed Duria A Rayis Mustafa I Elbashir Pregnant women carrying female fetuses are at higher risk of placental malaria infection. PLoS ONE |
| title | Pregnant women carrying female fetuses are at higher risk of placental malaria infection. |
| title_full | Pregnant women carrying female fetuses are at higher risk of placental malaria infection. |
| title_fullStr | Pregnant women carrying female fetuses are at higher risk of placental malaria infection. |
| title_full_unstemmed | Pregnant women carrying female fetuses are at higher risk of placental malaria infection. |
| title_short | Pregnant women carrying female fetuses are at higher risk of placental malaria infection. |
| title_sort | pregnant women carrying female fetuses are at higher risk of placental malaria infection |
| url | http://europepmc.org/articles/PMC5533337?pdf=render |
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