Design and Preparation of Sensing Surfaces for Capacitive Biodetection
Despite their high sensitivity and their suitability for miniaturization, biosensors are still limited for clinical applications due to the lack of reproducibility and specificity of their detection performance. The design and preparation of sensing surfaces are suspected to be a cause of these limi...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/13/1/17 |
| _version_ | 1827628054598385664 |
|---|---|
| author | Perrine Robin Sandrine Gerber-Lemaire |
| author_facet | Perrine Robin Sandrine Gerber-Lemaire |
| author_sort | Perrine Robin |
| collection | DOAJ |
| description | Despite their high sensitivity and their suitability for miniaturization, biosensors are still limited for clinical applications due to the lack of reproducibility and specificity of their detection performance. The design and preparation of sensing surfaces are suspected to be a cause of these limitations. Here, we first present an updated overview of the current state of use of capacitive biosensors in a medical context. Then, we summarize the encountered strategies for the fabrication of capacitive biosensing surfaces. Finally, we describe the characteristics which govern the performance of the sensing surfaces, along with recent developments that were suggested to overcome their main current limitations. |
| first_indexed | 2024-03-09T13:25:26Z |
| format | Article |
| id | doaj.art-82cf31d579ac41a294fde830197fd22f |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T13:25:26Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-82cf31d579ac41a294fde830197fd22f2023-11-30T21:24:17ZengMDPI AGBiosensors2079-63742022-12-011311710.3390/bios13010017Design and Preparation of Sensing Surfaces for Capacitive BiodetectionPerrine Robin0Sandrine Gerber-Lemaire1Group for Functionalized Biomaterials, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, SwitzerlandGroup for Functionalized Biomaterials, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, SwitzerlandDespite their high sensitivity and their suitability for miniaturization, biosensors are still limited for clinical applications due to the lack of reproducibility and specificity of their detection performance. The design and preparation of sensing surfaces are suspected to be a cause of these limitations. Here, we first present an updated overview of the current state of use of capacitive biosensors in a medical context. Then, we summarize the encountered strategies for the fabrication of capacitive biosensing surfaces. Finally, we describe the characteristics which govern the performance of the sensing surfaces, along with recent developments that were suggested to overcome their main current limitations.https://www.mdpi.com/2079-6374/13/1/17non-faradaic impedancecapacitive detectionbiosensorselectrochemical impedance spectroscopysurface functionalizationbiomolecules immobilization |
| spellingShingle | Perrine Robin Sandrine Gerber-Lemaire Design and Preparation of Sensing Surfaces for Capacitive Biodetection Biosensors non-faradaic impedance capacitive detection biosensors electrochemical impedance spectroscopy surface functionalization biomolecules immobilization |
| title | Design and Preparation of Sensing Surfaces for Capacitive Biodetection |
| title_full | Design and Preparation of Sensing Surfaces for Capacitive Biodetection |
| title_fullStr | Design and Preparation of Sensing Surfaces for Capacitive Biodetection |
| title_full_unstemmed | Design and Preparation of Sensing Surfaces for Capacitive Biodetection |
| title_short | Design and Preparation of Sensing Surfaces for Capacitive Biodetection |
| title_sort | design and preparation of sensing surfaces for capacitive biodetection |
| topic | non-faradaic impedance capacitive detection biosensors electrochemical impedance spectroscopy surface functionalization biomolecules immobilization |
| url | https://www.mdpi.com/2079-6374/13/1/17 |
| work_keys_str_mv | AT perrinerobin designandpreparationofsensingsurfacesforcapacitivebiodetection AT sandrinegerberlemaire designandpreparationofsensingsurfacesforcapacitivebiodetection |