Iron metabolism and ferroptosis: A pathway for understanding preeclampsia
Preeclampsia (PE) is a serious medical condition that poses a significant health risk to women and children worldwide, particularly in the middle- and low-income countries. It is a complex syndrome that occurs as a result of abnormal pregnancy. Hypertension is the most common symptom of PE, with pro...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222301363X |
| _version_ | 1797660517590892544 |
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| author | Khanisyah Erza Gumilar Bayu Priangga Chien-Hsing Lu Erry Gumilar Dachlan Ming Tan |
| author_facet | Khanisyah Erza Gumilar Bayu Priangga Chien-Hsing Lu Erry Gumilar Dachlan Ming Tan |
| author_sort | Khanisyah Erza Gumilar |
| collection | DOAJ |
| description | Preeclampsia (PE) is a serious medical condition that poses a significant health risk to women and children worldwide, particularly in the middle- and low-income countries. It is a complex syndrome that occurs as a result of abnormal pregnancy. Hypertension is the most common symptom of PE, with proteinuria and specific organ systems as detrimental targets. PE’s pathogenesis is diverse, and its symptoms can overlap with other diseases. In early pregnancy, when the placenta takes over control, oxidative stress may be closely associated with ferroptosis, a type of cell death caused by intracellular iron accumulation. Ferroptosis in the placenta is defined by redox-active iron availability, loss of antioxidant capacity and phospholipids containing polyunsaturated fatty acids (PUFA) oxidation. Recent studies suggest a compelling potential link between ferroptosis and PE. In this article, we comprehensively review the current understanding of PE and discuss one of its emerging underlying mechanisms, the ferroptosis pathway. We also provide perspective and analysis on the implications of this process in the diagnosis, prevention, and treatment of preeclampsia. We aim to bridge the gap between clinicians and basic scientists in understanding this harmful disease and challenge the research community to put more effort into this exciting new area. |
| first_indexed | 2024-03-11T18:32:03Z |
| format | Article |
| id | doaj.art-82cf7a416bc2469496d903df5526c1ce |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-11T18:32:03Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-82cf7a416bc2469496d903df5526c1ce2023-10-13T11:03:08ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-11-01167115565Iron metabolism and ferroptosis: A pathway for understanding preeclampsiaKhanisyah Erza Gumilar0Bayu Priangga1Chien-Hsing Lu2Erry Gumilar Dachlan3Ming Tan4Graduate Institute of Biomedical Science, China Medical University, Taichung 406040, Taiwan, ROC; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya 60115, IndonesiaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya 60115, IndonesiaDepartment of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung 40705, Taiwan, ROCDepartment of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya 60115, IndonesiaGraduate Institute of Biomedical Science, China Medical University, Taichung 406040, Taiwan, ROC; Institute of Biochemistry & Molecular Biology, and Research Center for Cancer Biology, China Medical University, Taichung 406040, Taiwan, ROC; Corresponding author at: Graduate Institute of Biomedical Science, China Medical University, Taichung 406040, Taiwan, ROC.Preeclampsia (PE) is a serious medical condition that poses a significant health risk to women and children worldwide, particularly in the middle- and low-income countries. It is a complex syndrome that occurs as a result of abnormal pregnancy. Hypertension is the most common symptom of PE, with proteinuria and specific organ systems as detrimental targets. PE’s pathogenesis is diverse, and its symptoms can overlap with other diseases. In early pregnancy, when the placenta takes over control, oxidative stress may be closely associated with ferroptosis, a type of cell death caused by intracellular iron accumulation. Ferroptosis in the placenta is defined by redox-active iron availability, loss of antioxidant capacity and phospholipids containing polyunsaturated fatty acids (PUFA) oxidation. Recent studies suggest a compelling potential link between ferroptosis and PE. In this article, we comprehensively review the current understanding of PE and discuss one of its emerging underlying mechanisms, the ferroptosis pathway. We also provide perspective and analysis on the implications of this process in the diagnosis, prevention, and treatment of preeclampsia. We aim to bridge the gap between clinicians and basic scientists in understanding this harmful disease and challenge the research community to put more effort into this exciting new area.http://www.sciencedirect.com/science/article/pii/S075333222301363XAbnormal pregnancyCell deathPreeclampsiaFerroptosisOxidative stressIron Metabolism |
| spellingShingle | Khanisyah Erza Gumilar Bayu Priangga Chien-Hsing Lu Erry Gumilar Dachlan Ming Tan Iron metabolism and ferroptosis: A pathway for understanding preeclampsia Biomedicine & Pharmacotherapy Abnormal pregnancy Cell death Preeclampsia Ferroptosis Oxidative stress Iron Metabolism |
| title | Iron metabolism and ferroptosis: A pathway for understanding preeclampsia |
| title_full | Iron metabolism and ferroptosis: A pathway for understanding preeclampsia |
| title_fullStr | Iron metabolism and ferroptosis: A pathway for understanding preeclampsia |
| title_full_unstemmed | Iron metabolism and ferroptosis: A pathway for understanding preeclampsia |
| title_short | Iron metabolism and ferroptosis: A pathway for understanding preeclampsia |
| title_sort | iron metabolism and ferroptosis a pathway for understanding preeclampsia |
| topic | Abnormal pregnancy Cell death Preeclampsia Ferroptosis Oxidative stress Iron Metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S075333222301363X |
| work_keys_str_mv | AT khanisyaherzagumilar ironmetabolismandferroptosisapathwayforunderstandingpreeclampsia AT bayupriangga ironmetabolismandferroptosisapathwayforunderstandingpreeclampsia AT chienhsinglu ironmetabolismandferroptosisapathwayforunderstandingpreeclampsia AT errygumilardachlan ironmetabolismandferroptosisapathwayforunderstandingpreeclampsia AT mingtan ironmetabolismandferroptosisapathwayforunderstandingpreeclampsia |