Silymarin protects against high fat diet-evoked metabolic injury by induction of glucagon-like peptide 1 and sirtuin 1
High-fat diet (HFD) is one of the major causes of increased prevalence of the metabolic syndrome. In this study, effect of silymarin on prevention and improvement of metabolic injury in HFD-induced rats was assessed. Results showed that silymarin intervention from 0 week or 8th week of the time cour...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-05-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619301306 |
| _version_ | 1819020812384993280 |
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| author | Kai-Jyun Chang Jer-An Lin Sheng-Yi Chen Ming-Hung Weng Gow-Chin Yen |
| author_facet | Kai-Jyun Chang Jer-An Lin Sheng-Yi Chen Ming-Hung Weng Gow-Chin Yen |
| author_sort | Kai-Jyun Chang |
| collection | DOAJ |
| description | High-fat diet (HFD) is one of the major causes of increased prevalence of the metabolic syndrome. In this study, effect of silymarin on prevention and improvement of metabolic injury in HFD-induced rats was assessed. Results showed that silymarin intervention from 0 week or 8th week of the time course in the experiment significantly improved metabolic syndromes, including insulin resistance and dyslipidemia in high fat diet-treated rats. Silymarin also can ameliorate the HFD-impaired glucose tolerance and recover, further enhance HFD-impaired glucagon-like peptide 1 (GLP-1) secretion in these rats. Intervention of silymarin from 0 week can prevent HFD-induced hepatic steatosis, pancreas fibrosis, and decreased sirtuin 1 protein levels of pancreas and liver in rats. In conclusion, silymarin can prevent and ameliorate HFD-induced metabolic syndrome, as well as improvement of GLP-1 secretion and Sirt1 protein expression, suggesting that silymarin may be a potential food factor against metabolic injury. |
| first_indexed | 2024-12-21T03:57:09Z |
| format | Article |
| id | doaj.art-82d2d3e5d747426ebdba3010e7298386 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-21T03:57:09Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-82d2d3e5d747426ebdba3010e72983862022-12-21T19:16:49ZengElsevierJournal of Functional Foods1756-46462019-05-0156136144Silymarin protects against high fat diet-evoked metabolic injury by induction of glucagon-like peptide 1 and sirtuin 1Kai-Jyun Chang0Jer-An Lin1Sheng-Yi Chen2Ming-Hung Weng3Gow-Chin Yen4Department of Food Science and Biotechnology, National Chung Hsing University, 145 Xingda Road, Taichung 40227, TaiwanGraduate Institute of Food Safety, National Chung Hsing University, 145 Xingda Road, Taichung 40227, TaiwanDepartment of Food Science and Biotechnology, National Chung Hsing University, 145 Xingda Road, Taichung 40227, TaiwanDepartment of Food Science and Biotechnology, National Chung Hsing University, 145 Xingda Road, Taichung 40227, TaiwanDepartment of Food Science and Biotechnology, National Chung Hsing University, 145 Xingda Road, Taichung 40227, Taiwan; Graduate Institute of Food Safety, National Chung Hsing University, 145 Xingda Road, Taichung 40227, Taiwan; Corresponding author at: Department of Food Science and Biotechnology, National Chung Hsing University, 145 Xingda Road, Taichung 40227, Taiwan.High-fat diet (HFD) is one of the major causes of increased prevalence of the metabolic syndrome. In this study, effect of silymarin on prevention and improvement of metabolic injury in HFD-induced rats was assessed. Results showed that silymarin intervention from 0 week or 8th week of the time course in the experiment significantly improved metabolic syndromes, including insulin resistance and dyslipidemia in high fat diet-treated rats. Silymarin also can ameliorate the HFD-impaired glucose tolerance and recover, further enhance HFD-impaired glucagon-like peptide 1 (GLP-1) secretion in these rats. Intervention of silymarin from 0 week can prevent HFD-induced hepatic steatosis, pancreas fibrosis, and decreased sirtuin 1 protein levels of pancreas and liver in rats. In conclusion, silymarin can prevent and ameliorate HFD-induced metabolic syndrome, as well as improvement of GLP-1 secretion and Sirt1 protein expression, suggesting that silymarin may be a potential food factor against metabolic injury.http://www.sciencedirect.com/science/article/pii/S1756464619301306High fat dietSilymarinMetabolic syndromeGLP-1Sirt1 |
| spellingShingle | Kai-Jyun Chang Jer-An Lin Sheng-Yi Chen Ming-Hung Weng Gow-Chin Yen Silymarin protects against high fat diet-evoked metabolic injury by induction of glucagon-like peptide 1 and sirtuin 1 Journal of Functional Foods High fat diet Silymarin Metabolic syndrome GLP-1 Sirt1 |
| title | Silymarin protects against high fat diet-evoked metabolic injury by induction of glucagon-like peptide 1 and sirtuin 1 |
| title_full | Silymarin protects against high fat diet-evoked metabolic injury by induction of glucagon-like peptide 1 and sirtuin 1 |
| title_fullStr | Silymarin protects against high fat diet-evoked metabolic injury by induction of glucagon-like peptide 1 and sirtuin 1 |
| title_full_unstemmed | Silymarin protects against high fat diet-evoked metabolic injury by induction of glucagon-like peptide 1 and sirtuin 1 |
| title_short | Silymarin protects against high fat diet-evoked metabolic injury by induction of glucagon-like peptide 1 and sirtuin 1 |
| title_sort | silymarin protects against high fat diet evoked metabolic injury by induction of glucagon like peptide 1 and sirtuin 1 |
| topic | High fat diet Silymarin Metabolic syndrome GLP-1 Sirt1 |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619301306 |
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