Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women
High fatty acid (FA) flux is associated with systemic insulin resistance, and African-American (AA) women tend to be more insulin resistant. We assessed possible depot and race difference in the antilipolytic effect of insulin in adipocytes isolated from abdominal (Abd) and gluteal (Glt) subcutaneou...
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| Format: | Article |
| Language: | English |
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Elsevier
2010-05-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520410752 |
| _version_ | 1818601431049961472 |
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| author | Susan K. Fried Thomas Tittelbach Jacob Blumenthal Urmila Sreenivasan Linda Robey Jamie Yi Sumbul Khan Courtney Hollender Alice S. Ryan Andrew P. Goldberg |
| author_facet | Susan K. Fried Thomas Tittelbach Jacob Blumenthal Urmila Sreenivasan Linda Robey Jamie Yi Sumbul Khan Courtney Hollender Alice S. Ryan Andrew P. Goldberg |
| author_sort | Susan K. Fried |
| collection | DOAJ |
| description | High fatty acid (FA) flux is associated with systemic insulin resistance, and African-American (AA) women tend to be more insulin resistant. We assessed possible depot and race difference in the antilipolytic effect of insulin in adipocytes isolated from abdominal (Abd) and gluteal (Glt) subcutaneous (sc) adipose tissue of overweight, postmenopausal AA and Caucasian (C) women. Percent body fat, fasting insulin, visceral adiposity, and adipocyte size was higher in AA women. Disinhibited lipolysis (presence of adenosine deaminase) per unit adipocyte surface area was similar in Abd and Glt and in AA and C. However, rates of 'basal’ [submaximal phenylisopropyl adenosine (PIA)-suppressed] and insulin-suppressed lipolysis were higher in Abd of AA compared with C women even after adjustment for percent fat and visceral fat area. The race difference in rates of PIA- and insulin-suppressed lipolysis in AA were correlated with their hyperinsulinemia, but AA race, independent of fasting insulin, was associated with lower responsiveness (percent suppression) to submaximal insulin concentrations, although sensitivity (ED50) was not affected. Overall, these data are consistent with the hypothesis that decreased responsiveness of Abd adipocytes to antilipolytic effectors may contribute to higher FA availability and thereby to racial differences in insulin resistance. |
| first_indexed | 2024-12-16T12:51:16Z |
| format | Article |
| id | doaj.art-82d321c36579484d92481d6f38181a3b |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-16T12:51:16Z |
| publishDate | 2010-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-82d321c36579484d92481d6f38181a3b2022-12-21T22:31:09ZengElsevierJournal of Lipid Research0022-22752010-05-0151511931200Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal womenSusan K. Fried0Thomas Tittelbach1Jacob Blumenthal2Urmila Sreenivasan3Linda Robey4Jamie Yi5Sumbul Khan6Courtney Hollender7Alice S. Ryan8Andrew P. Goldberg9To whom correspondence should be addressed. Current address: 650 Albany St., EBRC Rm 815, Boston, MA 02118; Geriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD; Divisions of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MDGeriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MDGeriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MDGeriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MDGeriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MDGeriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MDGeriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MDGeriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MDGeriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD; Gerontology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MDGeriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD; Gerontology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MDHigh fatty acid (FA) flux is associated with systemic insulin resistance, and African-American (AA) women tend to be more insulin resistant. We assessed possible depot and race difference in the antilipolytic effect of insulin in adipocytes isolated from abdominal (Abd) and gluteal (Glt) subcutaneous (sc) adipose tissue of overweight, postmenopausal AA and Caucasian (C) women. Percent body fat, fasting insulin, visceral adiposity, and adipocyte size was higher in AA women. Disinhibited lipolysis (presence of adenosine deaminase) per unit adipocyte surface area was similar in Abd and Glt and in AA and C. However, rates of 'basal’ [submaximal phenylisopropyl adenosine (PIA)-suppressed] and insulin-suppressed lipolysis were higher in Abd of AA compared with C women even after adjustment for percent fat and visceral fat area. The race difference in rates of PIA- and insulin-suppressed lipolysis in AA were correlated with their hyperinsulinemia, but AA race, independent of fasting insulin, was associated with lower responsiveness (percent suppression) to submaximal insulin concentrations, although sensitivity (ED50) was not affected. Overall, these data are consistent with the hypothesis that decreased responsiveness of Abd adipocytes to antilipolytic effectors may contribute to higher FA availability and thereby to racial differences in insulin resistance.http://www.sciencedirect.com/science/article/pii/S0022227520410752Adipose tissueadenosineinsulin sensitivityobesityrace |
| spellingShingle | Susan K. Fried Thomas Tittelbach Jacob Blumenthal Urmila Sreenivasan Linda Robey Jamie Yi Sumbul Khan Courtney Hollender Alice S. Ryan Andrew P. Goldberg Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women Journal of Lipid Research Adipose tissue adenosine insulin sensitivity obesity race |
| title | Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women |
| title_full | Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women |
| title_fullStr | Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women |
| title_full_unstemmed | Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women |
| title_short | Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women |
| title_sort | resistance to the antilipolytic effect of insulin in adipocytes of african american compared to caucasian postmenopausal women |
| topic | Adipose tissue adenosine insulin sensitivity obesity race |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520410752 |
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