Mixed Mycobacterium kansasii and Mycobacterium smegmatis infection in an adult‐onset immunodeficiency patient with anti‐interferon‐γ autoantibodies
Abstract Anti‐interferon‐gamma autoantibody (AIGA) is a rare adult‐onset immunodeficiency disease that increases the risk of occult infection. Nontuberculous mycobacteria (NTM) infections represent a diverse group of species and subspecies, and mixed infections with two or more NTM species have been...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.1178 |
| _version_ | 1797777277708140544 |
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| author | Yun‐Tse Chou Wei‐An Liao Chin‐Wei Kuo |
| author_facet | Yun‐Tse Chou Wei‐An Liao Chin‐Wei Kuo |
| author_sort | Yun‐Tse Chou |
| collection | DOAJ |
| description | Abstract Anti‐interferon‐gamma autoantibody (AIGA) is a rare adult‐onset immunodeficiency disease that increases the risk of occult infection. Nontuberculous mycobacteria (NTM) infections represent a diverse group of species and subspecies, and mixed infections with two or more NTM species have been reported. However, there is no consensus on the optimal antibiotics or immune modulator treatments for mixed NTM infections in AIGA patients. Here, we present the case of a 40‐year‐old female who initially presented with suspected lung cancer with obstructive pneumonitis. Tissue samples obtained through bronchoscopy, endoscopy, and bone marrow biopsy revealed disseminated mycobacterium infection. PCR‐based testing confirmed a mixed pulmonary infection with Mycobacterium kansasii and Mycobacterium smegmatis, as well as M. kansasii bacteremia. The patient received 12 months of anti‐NTM medications for M. kansasii, and the symptoms improved. Additionally, the images showed resolution after 6 months, even without the need for immune modulator treatment. |
| first_indexed | 2024-03-12T23:01:51Z |
| format | Article |
| id | doaj.art-82d3e16f6e6244cfb905a66f32a82ed0 |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-03-12T23:01:51Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-82d3e16f6e6244cfb905a66f32a82ed02023-07-19T10:41:33ZengWileyRespirology Case Reports2051-33802023-07-01117n/an/a10.1002/rcr2.1178Mixed Mycobacterium kansasii and Mycobacterium smegmatis infection in an adult‐onset immunodeficiency patient with anti‐interferon‐γ autoantibodiesYun‐Tse Chou0Wei‐An Liao1Chin‐Wei Kuo2Department of Internal Medicine National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan TaiwanDepartment of Pathology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan TaiwanDepartment of Internal Medicine National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan TaiwanAbstract Anti‐interferon‐gamma autoantibody (AIGA) is a rare adult‐onset immunodeficiency disease that increases the risk of occult infection. Nontuberculous mycobacteria (NTM) infections represent a diverse group of species and subspecies, and mixed infections with two or more NTM species have been reported. However, there is no consensus on the optimal antibiotics or immune modulator treatments for mixed NTM infections in AIGA patients. Here, we present the case of a 40‐year‐old female who initially presented with suspected lung cancer with obstructive pneumonitis. Tissue samples obtained through bronchoscopy, endoscopy, and bone marrow biopsy revealed disseminated mycobacterium infection. PCR‐based testing confirmed a mixed pulmonary infection with Mycobacterium kansasii and Mycobacterium smegmatis, as well as M. kansasii bacteremia. The patient received 12 months of anti‐NTM medications for M. kansasii, and the symptoms improved. Additionally, the images showed resolution after 6 months, even without the need for immune modulator treatment.https://doi.org/10.1002/rcr2.1178adult‐onset immunodeficiencyanti‐interferon‐γ autoantibodiesinterferon‐γ deficiencymycobacteria infection |
| spellingShingle | Yun‐Tse Chou Wei‐An Liao Chin‐Wei Kuo Mixed Mycobacterium kansasii and Mycobacterium smegmatis infection in an adult‐onset immunodeficiency patient with anti‐interferon‐γ autoantibodies Respirology Case Reports adult‐onset immunodeficiency anti‐interferon‐γ autoantibodies interferon‐γ deficiency mycobacteria infection |
| title | Mixed Mycobacterium kansasii and Mycobacterium smegmatis infection in an adult‐onset immunodeficiency patient with anti‐interferon‐γ autoantibodies |
| title_full | Mixed Mycobacterium kansasii and Mycobacterium smegmatis infection in an adult‐onset immunodeficiency patient with anti‐interferon‐γ autoantibodies |
| title_fullStr | Mixed Mycobacterium kansasii and Mycobacterium smegmatis infection in an adult‐onset immunodeficiency patient with anti‐interferon‐γ autoantibodies |
| title_full_unstemmed | Mixed Mycobacterium kansasii and Mycobacterium smegmatis infection in an adult‐onset immunodeficiency patient with anti‐interferon‐γ autoantibodies |
| title_short | Mixed Mycobacterium kansasii and Mycobacterium smegmatis infection in an adult‐onset immunodeficiency patient with anti‐interferon‐γ autoantibodies |
| title_sort | mixed mycobacterium kansasii and mycobacterium smegmatis infection in an adult onset immunodeficiency patient with anti interferon γ autoantibodies |
| topic | adult‐onset immunodeficiency anti‐interferon‐γ autoantibodies interferon‐γ deficiency mycobacteria infection |
| url | https://doi.org/10.1002/rcr2.1178 |
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