Factors Associated with Bacteremia and Fungemia in Cancer Patients
Although several advancements have been achieved in treatment of cancer patients, bacterial and fungal infections are still the most important cause of mortality. In this study, we aimed to determine factors associated with bacteremia and fungemia in cancer patients. In 71 hospitalized patients with...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bilimsel Tip Yayinevi
2000-03-01
|
| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2000-5-1-049-055.pdf |
| _version_ | 1797907829670019072 |
|---|---|
| author | Bülent ESER Mustafa ÇETİN Ali ÜNAL H. Şenol COŞKUN Üner KAYABAŞ Mustafa ALTINBAŞ |
| author_facet | Bülent ESER Mustafa ÇETİN Ali ÜNAL H. Şenol COŞKUN Üner KAYABAŞ Mustafa ALTINBAŞ |
| author_sort | Bülent ESER |
| collection | DOAJ |
| description | Although several advancements have been achieved in treatment of cancer patients, bacterial and fungal infections are still the most important cause of mortality. In this study, we aimed to determine factors associated with bacteremia and fungemia in cancer patients. In 71 hospitalized patients with cancer who were admitted to Hematology-Oncology department between January 1996 and May 1998, 54 (52%) neutropenic and 50 (48%) nonneutropenic febrile episodes were evaluated. In 22 (21%) of the cases bacteremia or fungemia was present. There was no relation between bacteremia or fungemia and age, sex, neutrophil counts, focus of infection, underlying disease, diarrhea and renal or liver dysfunction. For the cancer patients having central venous catheter, severe mucositis and platelet count lower than 20000/mm3, it was observed that the probability of fungemia or bacteremia was higher than the others. Twelve patients died during febrile episodes. The cause of death was related to infections in nine cases, and bleeding or other complications of the primary disease in three cases (infection related mortality rate: 8.7%). Gram-negative bacteria were causative organisms in five of the nine patients who died from infection. In conclusion; we determined that mucositis, central venous catheterization, and low platelet count in cancer patients increased the probability of
bacteremia or fungemia, while neutropenia did not have any effect on there. On the other hand, gram-negative bacterial infections have been found as the most important cause of mortality in cancer patients. |
| first_indexed | 2024-04-10T10:43:19Z |
| format | Article |
| id | doaj.art-82d52c56d7224ee0bf53f932f3a5c10b |
| institution | Directory Open Access Journal |
| issn | 1300-932X 1300-932X |
| language | English |
| last_indexed | 2024-04-10T10:43:19Z |
| publishDate | 2000-03-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-82d52c56d7224ee0bf53f932f3a5c10b2023-02-15T16:20:27ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X1300-932X2000-03-01514955Factors Associated with Bacteremia and Fungemia in Cancer PatientsBülent ESER0Mustafa ÇETİN1Ali ÜNAL2H. Şenol COŞKUN3Üner KAYABAŞ4Mustafa ALTINBAŞ5Erciyes Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji ve Onkoloji Bilim DalıErciyes Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji ve Onkoloji Bilim DalıErciyes Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji ve Onkoloji Bilim DalıErciyes Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji ve Onkoloji Bilim DalıErciyes Üniversitesi Tıp Fakültesi, Klinik Bakteriyoloji ve İnfeksiyon Hastalıkları Anabilim Dalı, KAYSERİErciyes Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Hematoloji ve Onkoloji Bilim DalıAlthough several advancements have been achieved in treatment of cancer patients, bacterial and fungal infections are still the most important cause of mortality. In this study, we aimed to determine factors associated with bacteremia and fungemia in cancer patients. In 71 hospitalized patients with cancer who were admitted to Hematology-Oncology department between January 1996 and May 1998, 54 (52%) neutropenic and 50 (48%) nonneutropenic febrile episodes were evaluated. In 22 (21%) of the cases bacteremia or fungemia was present. There was no relation between bacteremia or fungemia and age, sex, neutrophil counts, focus of infection, underlying disease, diarrhea and renal or liver dysfunction. For the cancer patients having central venous catheter, severe mucositis and platelet count lower than 20000/mm3, it was observed that the probability of fungemia or bacteremia was higher than the others. Twelve patients died during febrile episodes. The cause of death was related to infections in nine cases, and bleeding or other complications of the primary disease in three cases (infection related mortality rate: 8.7%). Gram-negative bacteria were causative organisms in five of the nine patients who died from infection. In conclusion; we determined that mucositis, central venous catheterization, and low platelet count in cancer patients increased the probability of bacteremia or fungemia, while neutropenia did not have any effect on there. On the other hand, gram-negative bacterial infections have been found as the most important cause of mortality in cancer patients.http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2000-5-1-049-055.pdfCancerFeverBacteremiaFungemia |
| spellingShingle | Bülent ESER Mustafa ÇETİN Ali ÜNAL H. Şenol COŞKUN Üner KAYABAŞ Mustafa ALTINBAŞ Factors Associated with Bacteremia and Fungemia in Cancer Patients Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi Cancer Fever Bacteremia Fungemia |
| title | Factors Associated with Bacteremia and Fungemia in Cancer Patients |
| title_full | Factors Associated with Bacteremia and Fungemia in Cancer Patients |
| title_fullStr | Factors Associated with Bacteremia and Fungemia in Cancer Patients |
| title_full_unstemmed | Factors Associated with Bacteremia and Fungemia in Cancer Patients |
| title_short | Factors Associated with Bacteremia and Fungemia in Cancer Patients |
| title_sort | factors associated with bacteremia and fungemia in cancer patients |
| topic | Cancer Fever Bacteremia Fungemia |
| url | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2000-5-1-049-055.pdf |
| work_keys_str_mv | AT bulenteser factorsassociatedwithbacteremiaandfungemiaincancerpatients AT mustafacetin factorsassociatedwithbacteremiaandfungemiaincancerpatients AT aliunal factorsassociatedwithbacteremiaandfungemiaincancerpatients AT hsenolcoskun factorsassociatedwithbacteremiaandfungemiaincancerpatients AT unerkayabas factorsassociatedwithbacteremiaandfungemiaincancerpatients AT mustafaaltinbas factorsassociatedwithbacteremiaandfungemiaincancerpatients |