The functional mutational landscape of the lacZ gene

The functional mutational landscape of the lacZ gene

Summary: The lacZ gene of Escherichia coli encodes β-galactosidase (β-gal), a lactose metabolism enzyme of the lactose operon. Previous chemical modification or site-directed mutagenesis experiments have identified 21 amino acids that are essential for β-gal catalytic activity. We have assembled ove...

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Bibliographic Details
Main Authors:	Marc A. Beal, Matthew J. Meier, Angela Dykes, Carole L. Yauk, Iain B. Lambert, Francesco Marchetti
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Series:	iScience
Subjects:	Genetics Molecular genetics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004223024847

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