Day-night and seasonal variation of human gene expression across tissues.
Circadian and circannual cycles trigger physiological changes whose reflection on human transcriptomes remains largely uncharted. We used the time and season of death of 932 individuals from GTEx to jointly investigate transcriptomic changes associated with those cycles across multiple tissues. Over...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-02-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3001986 |
| _version_ | 1797894671641346048 |
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| author | Valentin Wucher Reza Sodaei Raziel Amador Manuel Irimia Roderic Guigó |
| author_facet | Valentin Wucher Reza Sodaei Raziel Amador Manuel Irimia Roderic Guigó |
| author_sort | Valentin Wucher |
| collection | DOAJ |
| description | Circadian and circannual cycles trigger physiological changes whose reflection on human transcriptomes remains largely uncharted. We used the time and season of death of 932 individuals from GTEx to jointly investigate transcriptomic changes associated with those cycles across multiple tissues. Overall, most variation across tissues during day-night and among seasons was unique to each cycle. Although all tissues remodeled their transcriptomes, brain and gonadal tissues exhibited the highest seasonality, whereas those in the thoracic cavity showed stronger day-night regulation. Core clock genes displayed marked day-night differences across multiple tissues, which were largely conserved in baboon and mouse, but adapted to their nocturnal or diurnal habits. Seasonal variation of expression affected multiple pathways, and it was enriched among genes associated with the immune response, consistent with the seasonality of viral infections. Furthermore, they unveiled cytoarchitectural changes in brain regions. Altogether, our results provide the first combined atlas of how transcriptomes from human tissues adapt to major cycling environmental conditions. This atlas may have multiple applications; for example, drug targets with day-night or seasonal variation in gene expression may benefit from temporally adjusted doses. |
| first_indexed | 2024-04-10T07:13:00Z |
| format | Article |
| id | doaj.art-82d58d397cbc49aeb0eb05da427a7784 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-04-10T07:13:00Z |
| publishDate | 2023-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-82d58d397cbc49aeb0eb05da427a77842023-02-26T05:30:49ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852023-02-01212e300198610.1371/journal.pbio.3001986Day-night and seasonal variation of human gene expression across tissues.Valentin WucherReza SodaeiRaziel AmadorManuel IrimiaRoderic GuigóCircadian and circannual cycles trigger physiological changes whose reflection on human transcriptomes remains largely uncharted. We used the time and season of death of 932 individuals from GTEx to jointly investigate transcriptomic changes associated with those cycles across multiple tissues. Overall, most variation across tissues during day-night and among seasons was unique to each cycle. Although all tissues remodeled their transcriptomes, brain and gonadal tissues exhibited the highest seasonality, whereas those in the thoracic cavity showed stronger day-night regulation. Core clock genes displayed marked day-night differences across multiple tissues, which were largely conserved in baboon and mouse, but adapted to their nocturnal or diurnal habits. Seasonal variation of expression affected multiple pathways, and it was enriched among genes associated with the immune response, consistent with the seasonality of viral infections. Furthermore, they unveiled cytoarchitectural changes in brain regions. Altogether, our results provide the first combined atlas of how transcriptomes from human tissues adapt to major cycling environmental conditions. This atlas may have multiple applications; for example, drug targets with day-night or seasonal variation in gene expression may benefit from temporally adjusted doses.https://doi.org/10.1371/journal.pbio.3001986 |
| spellingShingle | Valentin Wucher Reza Sodaei Raziel Amador Manuel Irimia Roderic Guigó Day-night and seasonal variation of human gene expression across tissues. PLoS Biology |
| title | Day-night and seasonal variation of human gene expression across tissues. |
| title_full | Day-night and seasonal variation of human gene expression across tissues. |
| title_fullStr | Day-night and seasonal variation of human gene expression across tissues. |
| title_full_unstemmed | Day-night and seasonal variation of human gene expression across tissues. |
| title_short | Day-night and seasonal variation of human gene expression across tissues. |
| title_sort | day night and seasonal variation of human gene expression across tissues |
| url | https://doi.org/10.1371/journal.pbio.3001986 |
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