How HTLV-1 may subvert miRNAs for persistence and transformation
<p>Abstract</p> <p>Distinct mechanisms are used by viruses to interact with cellular miRNAs. The role of microRNAs in viral replication and persistence ranges from viral-encoded microRNAs to suppressors of RNA interference. Viruses can also exploit cellular miRNAs for influencing c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-11-01
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| Series: | Retrovirology |
| Online Access: | http://www.retrovirology.com/content/5/1/101 |
| _version_ | 1828297585434034176 |
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| author | Bouzar Amel B Willems Luc |
| author_facet | Bouzar Amel B Willems Luc |
| author_sort | Bouzar Amel B |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Distinct mechanisms are used by viruses to interact with cellular miRNAs. The role of microRNAs in viral replication and persistence ranges from viral-encoded microRNAs to suppressors of RNA interference. Viruses can also exploit cellular miRNAs for influencing cellular metabolism to ensure efficient replication or latency. In particular, two recent studies provide examples of how HTLV-1 may co-opt or subvert cellular miRNAs for persistent replication and oncogenic purposes. The pathways modulated by these described miRNAs are critically involved in apoptosis, proliferation and innate immune response.</p> |
| first_indexed | 2024-04-13T12:28:58Z |
| format | Article |
| id | doaj.art-82d5b7df954348d08e6aef339fbeb8e5 |
| institution | Directory Open Access Journal |
| issn | 1742-4690 |
| language | English |
| last_indexed | 2024-04-13T12:28:58Z |
| publishDate | 2008-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Retrovirology |
| spelling | doaj.art-82d5b7df954348d08e6aef339fbeb8e52022-12-22T02:46:56ZengBMCRetrovirology1742-46902008-11-015110110.1186/1742-4690-5-101How HTLV-1 may subvert miRNAs for persistence and transformationBouzar Amel BWillems Luc<p>Abstract</p> <p>Distinct mechanisms are used by viruses to interact with cellular miRNAs. The role of microRNAs in viral replication and persistence ranges from viral-encoded microRNAs to suppressors of RNA interference. Viruses can also exploit cellular miRNAs for influencing cellular metabolism to ensure efficient replication or latency. In particular, two recent studies provide examples of how HTLV-1 may co-opt or subvert cellular miRNAs for persistent replication and oncogenic purposes. The pathways modulated by these described miRNAs are critically involved in apoptosis, proliferation and innate immune response.</p>http://www.retrovirology.com/content/5/1/101 |
| spellingShingle | Bouzar Amel B Willems Luc How HTLV-1 may subvert miRNAs for persistence and transformation Retrovirology |
| title | How HTLV-1 may subvert miRNAs for persistence and transformation |
| title_full | How HTLV-1 may subvert miRNAs for persistence and transformation |
| title_fullStr | How HTLV-1 may subvert miRNAs for persistence and transformation |
| title_full_unstemmed | How HTLV-1 may subvert miRNAs for persistence and transformation |
| title_short | How HTLV-1 may subvert miRNAs for persistence and transformation |
| title_sort | how htlv 1 may subvert mirnas for persistence and transformation |
| url | http://www.retrovirology.com/content/5/1/101 |
| work_keys_str_mv | AT bouzaramelb howhtlv1maysubvertmirnasforpersistenceandtransformation AT willemsluc howhtlv1maysubvertmirnasforpersistenceandtransformation |