EEG complexity correlates with residual consciousness level of disorders of consciousness
Abstract Background and objective Electroencephalography (EEG) and neuroimaging measurements have been highly encouraged to be applied in clinics of disorders of consciousness (DOC) to improve consciousness detection. We tested the relationships between neural complexity measured on EEG and residual...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-023-03167-w |
| _version_ | 1797849973716418560 |
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| author | Yangfeng Liu Wentao Zeng Na Pan Xiaoyu Xia Yonghua Huang Jianghong He |
| author_facet | Yangfeng Liu Wentao Zeng Na Pan Xiaoyu Xia Yonghua Huang Jianghong He |
| author_sort | Yangfeng Liu |
| collection | DOAJ |
| description | Abstract Background and objective Electroencephalography (EEG) and neuroimaging measurements have been highly encouraged to be applied in clinics of disorders of consciousness (DOC) to improve consciousness detection. We tested the relationships between neural complexity measured on EEG and residual consciousness levels in DOC patients. Methods Resting-state EEG was recorded from twenty-five patients with DOC. Lempel–Ziv complexity (LZC) and permutation Lempel–Ziv complexity (PLZC) were measured on the EEG, and their relationships were analyzed with the consciousness levels of the patients. Results PLZC and LZC values significantly distinguished patients with a minimally conscious state (MCS), vegetative state/unresponsive wakefulness syndrome (VS/UWS), and healthy controls. PLZC was significantly correlated with the Coma Recovery Scale-Revised (CRS-R) scores of DOC patients in the global brain, particularly in electrodes locating in the anterior and posterior brain regions. Patients with higher CRS-R scores showed higher PLZC values. The significant difference in PLZC values between MCS and VS/UWS was mainly located in the bilateral frontal and right hemisphere regions. Conclusion Neural complexity measured on EEG correlates with residual consciousness levels of DOC patients. PLZC showed higher sensitivity than LZC in the classification of consciousness levels. |
| first_indexed | 2024-04-09T18:53:57Z |
| format | Article |
| id | doaj.art-82d5c3fabdc544de8ae8ac30c8843d40 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-09T18:53:57Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-82d5c3fabdc544de8ae8ac30c8843d402023-04-09T11:19:56ZengBMCBMC Neurology1471-23772023-04-012311910.1186/s12883-023-03167-wEEG complexity correlates with residual consciousness level of disorders of consciousnessYangfeng Liu0Wentao Zeng1Na Pan2Xiaoyu Xia3Yonghua Huang4Jianghong He5Xijing 986 Hospital Department, Fourth Military Medical UniversityDepartment of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong UniversityXijing 986 Hospital Department, Fourth Military Medical UniversityThe Seventh Medical Center of PLA General HospitalThe Seventh Medical Center of PLA General HospitalDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background and objective Electroencephalography (EEG) and neuroimaging measurements have been highly encouraged to be applied in clinics of disorders of consciousness (DOC) to improve consciousness detection. We tested the relationships between neural complexity measured on EEG and residual consciousness levels in DOC patients. Methods Resting-state EEG was recorded from twenty-five patients with DOC. Lempel–Ziv complexity (LZC) and permutation Lempel–Ziv complexity (PLZC) were measured on the EEG, and their relationships were analyzed with the consciousness levels of the patients. Results PLZC and LZC values significantly distinguished patients with a minimally conscious state (MCS), vegetative state/unresponsive wakefulness syndrome (VS/UWS), and healthy controls. PLZC was significantly correlated with the Coma Recovery Scale-Revised (CRS-R) scores of DOC patients in the global brain, particularly in electrodes locating in the anterior and posterior brain regions. Patients with higher CRS-R scores showed higher PLZC values. The significant difference in PLZC values between MCS and VS/UWS was mainly located in the bilateral frontal and right hemisphere regions. Conclusion Neural complexity measured on EEG correlates with residual consciousness levels of DOC patients. PLZC showed higher sensitivity than LZC in the classification of consciousness levels.https://doi.org/10.1186/s12883-023-03167-wLempel–Ziv complexityEEGDisorders of consciousnessMinimally conscious state |
| spellingShingle | Yangfeng Liu Wentao Zeng Na Pan Xiaoyu Xia Yonghua Huang Jianghong He EEG complexity correlates with residual consciousness level of disorders of consciousness BMC Neurology Lempel–Ziv complexity EEG Disorders of consciousness Minimally conscious state |
| title | EEG complexity correlates with residual consciousness level of disorders of consciousness |
| title_full | EEG complexity correlates with residual consciousness level of disorders of consciousness |
| title_fullStr | EEG complexity correlates with residual consciousness level of disorders of consciousness |
| title_full_unstemmed | EEG complexity correlates with residual consciousness level of disorders of consciousness |
| title_short | EEG complexity correlates with residual consciousness level of disorders of consciousness |
| title_sort | eeg complexity correlates with residual consciousness level of disorders of consciousness |
| topic | Lempel–Ziv complexity EEG Disorders of consciousness Minimally conscious state |
| url | https://doi.org/10.1186/s12883-023-03167-w |
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