The Role of Gender in Chronic Kidney Disease
Chronic kidney disease (CKD) is a common disease worldwide and is associated with high rates of morbidity and mortality. This review discusses several aspects of the relationship between gender and CKD. While the prevalence of CKD tends to be higher in women, the disease is more severe in men, who a...
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| Format: | Article |
| Language: | English |
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European Medical Journal
2016-04-01
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| Series: | European Medical Journal |
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| Online Access: | https://emj.emg-health.com/wp-content/uploads/sites/2/2017/12/The-Role-of-Gender-in-Chronic-Kidney-Disease.pdf |
| _version_ | 1819227362207727616 |
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| author | Idan Goldberg Ilan Krause |
| author_facet | Idan Goldberg Ilan Krause |
| author_sort | Idan Goldberg |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is a common disease worldwide and is associated with high rates of morbidity and mortality. This review discusses several aspects of the relationship between gender and CKD. While the prevalence of CKD tends to be higher in women, the disease is more severe in men, who also have a higher prevalence of end-stage renal disease. Most of the evidence in the current literature suggests a higher progression rate and mortality risk of CKD in men compared with women, except in post-menopausal women and diabetic patients. However, the decrease in glomerular filtration rate and the increase in the level of albuminuria are more prominent mortality risk factors among women. Sex hormones are thought to play a major role in the biological mechanisms associated with variability in CKD prevalence and characteristics between men and women. Animal studies have demonstrated the harmful influence of testosterone and protective influence of oestrogen on several biological processes that are involved in kidney injury. However, the role of sex hormones in explaining gender-related differences in CKD in humans has not yet been established. In summary, gender has an important influence on several aspects of CKD. Further research is needed to find additional gender-related characteristics in CKD and to identify the mechanisms of sexual dimorphism in CKD. |
| first_indexed | 2024-12-23T10:40:11Z |
| format | Article |
| id | doaj.art-82d65132e169415dad2a760f8af09b07 |
| institution | Directory Open Access Journal |
| issn | 2397-6764 |
| language | English |
| last_indexed | 2024-12-23T10:40:11Z |
| publishDate | 2016-04-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal |
| spelling | doaj.art-82d65132e169415dad2a760f8af09b072022-12-21T17:50:11ZengEuropean Medical JournalEuropean Medical Journal2397-67642016-04-01125864The Role of Gender in Chronic Kidney DiseaseIdan Goldberg0Ilan Krause1Rabin Medical Center, Beilinson Campus, Petah Tikva, IsraelRabin Medical Center, Beilinson Campus, Petah Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, IsraelChronic kidney disease (CKD) is a common disease worldwide and is associated with high rates of morbidity and mortality. This review discusses several aspects of the relationship between gender and CKD. While the prevalence of CKD tends to be higher in women, the disease is more severe in men, who also have a higher prevalence of end-stage renal disease. Most of the evidence in the current literature suggests a higher progression rate and mortality risk of CKD in men compared with women, except in post-menopausal women and diabetic patients. However, the decrease in glomerular filtration rate and the increase in the level of albuminuria are more prominent mortality risk factors among women. Sex hormones are thought to play a major role in the biological mechanisms associated with variability in CKD prevalence and characteristics between men and women. Animal studies have demonstrated the harmful influence of testosterone and protective influence of oestrogen on several biological processes that are involved in kidney injury. However, the role of sex hormones in explaining gender-related differences in CKD in humans has not yet been established. In summary, gender has an important influence on several aspects of CKD. Further research is needed to find additional gender-related characteristics in CKD and to identify the mechanisms of sexual dimorphism in CKD.https://emj.emg-health.com/wp-content/uploads/sites/2/2017/12/The-Role-of-Gender-in-Chronic-Kidney-Disease.pdfrenal failureglomerular filtration rate (gfr)sex hormonesend-stage renal disease (esrd) |
| spellingShingle | Idan Goldberg Ilan Krause The Role of Gender in Chronic Kidney Disease European Medical Journal renal failure glomerular filtration rate (gfr) sex hormones end-stage renal disease (esrd) |
| title | The Role of Gender in Chronic Kidney Disease |
| title_full | The Role of Gender in Chronic Kidney Disease |
| title_fullStr | The Role of Gender in Chronic Kidney Disease |
| title_full_unstemmed | The Role of Gender in Chronic Kidney Disease |
| title_short | The Role of Gender in Chronic Kidney Disease |
| title_sort | role of gender in chronic kidney disease |
| topic | renal failure glomerular filtration rate (gfr) sex hormones end-stage renal disease (esrd) |
| url | https://emj.emg-health.com/wp-content/uploads/sites/2/2017/12/The-Role-of-Gender-in-Chronic-Kidney-Disease.pdf |
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