Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases

Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases

Inhibition of bacterial virulence is believed to be a new treatment option for bacterial infections. In the present study, we tested dipicolylamine (DPA), tripicolylamine (TPA), tris pyridine ethylene diamine (TPED), pyridine and thiophene derivatives as putative inhibitors of the bacterial virulenc...

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Bibliographic Details
Main Authors: Fatema Rahman, Imin Wushur, Nabin Malla, Ove Alexander Høgmoen Åstrand, Pål Rongved, Jan-Olof Winberg, Ingebrigt Sylte
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
bacterial virulence factors
matrix metalloproteases
zinc chelators
enzyme inhibition
docking
molecular interactions
Online Access:https://www.mdpi.com/1420-3049/27/1/56

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