Prognosis, survival, and clinicopathological characteristics of small cell lung cancer with pleural fluid
Objective: While malignant pleural effusion (MPE) is generally observed in non-small cell lung cancer (SCLC) patients, its prevalence in SCLC has not been reported. Methods: Patients over 18 who were admitted to our hospital between January 2015 and December 2019 and diagnosed with SCLC histological...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Jaypee Brothers Medical Publisher
2022-01-01
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| Series: | Indian Journal of Respiratory Care |
| Subjects: | |
| Online Access: | http://www.ijrc.in/article.asp?issn=2277-9019;year=2022;volume=11;issue=2;spage=135;epage=139;aulast=Cimen |
| _version_ | 1797694450240061440 |
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| author | Filiz Cimen Melike Aloglu Sevim Düzgün Aysegül Senturk Sükran Atikcan |
| author_facet | Filiz Cimen Melike Aloglu Sevim Düzgün Aysegül Senturk Sükran Atikcan |
| author_sort | Filiz Cimen |
| collection | DOAJ |
| description | Objective: While malignant pleural effusion (MPE) is generally observed in non-small cell lung cancer (SCLC) patients, its prevalence in SCLC has not been reported. Methods: Patients over 18 who were admitted to our hospital between January 2015 and December 2019 and diagnosed with SCLC histologically were retrospectively studied. Demographic data, tumor location, tumor stage, pleural fluid characteristics, radiological findings, and overall survival were recorded from hospital records. Results: Our study included 59 patients (48 [81.4%] men and 11 [18.6%] women), with a median age of 67. Forty-seven (79.7%) patients had a history of smoking. The patients had median tumor standardized uptake values (SUV) max levels of 11.9, a tumor diameter of 6 cm, and a follow-up period of 7 months. Protein levels in pleural fluid of the metastasizing group were significantly higher than in the nonmetastatic group (P = 0.049). In the univariate model, age, N stage, pleural fluid glucose, and pleural fluid protein levels were found significantly efficient in predicting disease-free survival (P = 0.008, P = 0.001, P = 0.001, and P = 0.026, respectively). In the multivariate reduced model, N stage, pleural fluid glucose, and pleural fluid protein levels were found independent predictive factors for disease-free survival (P = 0.000, P = 0.000, and P = 0.009, respectively). Conclusions: MPE is common at presentation (11%) in patients with SCLC and may be associated with reduced survival. Additional studies are needed to assess the treatment-adjusted survival rate in the MPE setting. |
| first_indexed | 2024-03-12T02:57:11Z |
| format | Article |
| id | doaj.art-82dbf3e4271d4977978ddaa7a5a7da6b |
| institution | Directory Open Access Journal |
| issn | 2277-9019 2321-4899 |
| language | English |
| last_indexed | 2024-03-12T02:57:11Z |
| publishDate | 2022-01-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Indian Journal of Respiratory Care |
| spelling | doaj.art-82dbf3e4271d4977978ddaa7a5a7da6b2023-09-03T15:12:32ZengJaypee Brothers Medical PublisherIndian Journal of Respiratory Care2277-90192321-48992022-01-0111213513910.4103/ijrc.ijrc_155_21Prognosis, survival, and clinicopathological characteristics of small cell lung cancer with pleural fluidFiliz CimenMelike AlogluSevim DüzgünAysegül SenturkSükran AtikcanObjective: While malignant pleural effusion (MPE) is generally observed in non-small cell lung cancer (SCLC) patients, its prevalence in SCLC has not been reported. Methods: Patients over 18 who were admitted to our hospital between January 2015 and December 2019 and diagnosed with SCLC histologically were retrospectively studied. Demographic data, tumor location, tumor stage, pleural fluid characteristics, radiological findings, and overall survival were recorded from hospital records. Results: Our study included 59 patients (48 [81.4%] men and 11 [18.6%] women), with a median age of 67. Forty-seven (79.7%) patients had a history of smoking. The patients had median tumor standardized uptake values (SUV) max levels of 11.9, a tumor diameter of 6 cm, and a follow-up period of 7 months. Protein levels in pleural fluid of the metastasizing group were significantly higher than in the nonmetastatic group (P = 0.049). In the univariate model, age, N stage, pleural fluid glucose, and pleural fluid protein levels were found significantly efficient in predicting disease-free survival (P = 0.008, P = 0.001, P = 0.001, and P = 0.026, respectively). In the multivariate reduced model, N stage, pleural fluid glucose, and pleural fluid protein levels were found independent predictive factors for disease-free survival (P = 0.000, P = 0.000, and P = 0.009, respectively). Conclusions: MPE is common at presentation (11%) in patients with SCLC and may be associated with reduced survival. Additional studies are needed to assess the treatment-adjusted survival rate in the MPE setting.http://www.ijrc.in/article.asp?issn=2277-9019;year=2022;volume=11;issue=2;spage=135;epage=139;aulast=Cimenlung cancerpleural fluidpleural fluid proteinprognosissmall-cell lung cancer |
| spellingShingle | Filiz Cimen Melike Aloglu Sevim Düzgün Aysegül Senturk Sükran Atikcan Prognosis, survival, and clinicopathological characteristics of small cell lung cancer with pleural fluid Indian Journal of Respiratory Care lung cancer pleural fluid pleural fluid protein prognosis small-cell lung cancer |
| title | Prognosis, survival, and clinicopathological characteristics of small cell lung cancer with pleural fluid |
| title_full | Prognosis, survival, and clinicopathological characteristics of small cell lung cancer with pleural fluid |
| title_fullStr | Prognosis, survival, and clinicopathological characteristics of small cell lung cancer with pleural fluid |
| title_full_unstemmed | Prognosis, survival, and clinicopathological characteristics of small cell lung cancer with pleural fluid |
| title_short | Prognosis, survival, and clinicopathological characteristics of small cell lung cancer with pleural fluid |
| title_sort | prognosis survival and clinicopathological characteristics of small cell lung cancer with pleural fluid |
| topic | lung cancer pleural fluid pleural fluid protein prognosis small-cell lung cancer |
| url | http://www.ijrc.in/article.asp?issn=2277-9019;year=2022;volume=11;issue=2;spage=135;epage=139;aulast=Cimen |
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