Evaluation of Efficacy of Two Different Doses of Intravenous Lidocaine in Patients with Chronic Pain
Background: An intravenous infusion of lidocaine has been used on numerous occasions to produce analgesia in neuropathic pain. It has been shown to be beneficial for the treatment of variety of neuropathic pain states in a wide range of dosage, from 2 to 7.5 mg/kg. The aim of our study was to evalua...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | MAMC Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.mamcjms.in/article.asp?issn=2394-7438;year=2023;volume=9;issue=1;spage=13;epage=17;aulast=Ghai |
| _version_ | 1797775425789755392 |
|---|---|
| author | Anju Ghai Bharti Verma Kanika Rohilla |
| author_facet | Anju Ghai Bharti Verma Kanika Rohilla |
| author_sort | Anju Ghai |
| collection | DOAJ |
| description | Background: An intravenous infusion of lidocaine has been used on numerous occasions to produce analgesia in neuropathic pain. It has been shown to be beneficial for the treatment of variety of neuropathic pain states in a wide range of dosage, from 2 to 7.5 mg/kg. The aim of our study was to evaluate the efficacy of two different doses of intravenous lidocaine (3 and 4 mg/kg) in patients with chronic pain. Methods: Patients above the age of 18 years suffering from chronic pain due to postherpetic neuralgia, post-surgical scar pain, chronic low back pain having numeric analogue scale (NAS) pain score of ≥3 without satisfactory pain relief from conservative treatment were randomised to receive either 3 mg/kg or 4 mg/kg intravenous lidocaine in 250 mL normal saline infusions weekly over a period of 1 hour for 3 weeks. NAS was measured before starting each infusion, immediately after completion of infusion, 2 and 24 hours, 7th day, 14th day, 21st day, and 28th day. Results: NAS score at first hour and 24th hour was significantly reduced (P = 0.001), after each infusion [7th, 14th day] in both the groups. There was no statistical difference in pain score among both groups except for day 7 (P value 0.04). Reduction in NAS score was also present on 21st and 28th day in both groups, but it did not reach a significant value. On 28th day, NAS score values showed increasing trend. Duration of pain relief was around 1 week after each infusion in both groups. Conclusion: Intravenous lidocaine at a dose of 3 mg/kg or 4 mg/kg was effective in reducing pain in patients with chronic pain. The analgesic effect was not different among both groups. Trend of greater response was observed with 4 mg/kg dose. |
| first_indexed | 2024-03-12T22:35:34Z |
| format | Article |
| id | doaj.art-82dc0e4785df440598a79f7ee7c5ac96 |
| institution | Directory Open Access Journal |
| issn | 2394-7438 |
| language | English |
| last_indexed | 2024-03-12T22:35:34Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | MAMC Journal of Medical Sciences |
| spelling | doaj.art-82dc0e4785df440598a79f7ee7c5ac962023-07-21T12:45:25ZengWolters Kluwer Medknow PublicationsMAMC Journal of Medical Sciences2394-74382023-01-0191131710.4103/mamcjms.mamcjms_7_23Evaluation of Efficacy of Two Different Doses of Intravenous Lidocaine in Patients with Chronic PainAnju GhaiBharti VermaKanika RohillaBackground: An intravenous infusion of lidocaine has been used on numerous occasions to produce analgesia in neuropathic pain. It has been shown to be beneficial for the treatment of variety of neuropathic pain states in a wide range of dosage, from 2 to 7.5 mg/kg. The aim of our study was to evaluate the efficacy of two different doses of intravenous lidocaine (3 and 4 mg/kg) in patients with chronic pain. Methods: Patients above the age of 18 years suffering from chronic pain due to postherpetic neuralgia, post-surgical scar pain, chronic low back pain having numeric analogue scale (NAS) pain score of ≥3 without satisfactory pain relief from conservative treatment were randomised to receive either 3 mg/kg or 4 mg/kg intravenous lidocaine in 250 mL normal saline infusions weekly over a period of 1 hour for 3 weeks. NAS was measured before starting each infusion, immediately after completion of infusion, 2 and 24 hours, 7th day, 14th day, 21st day, and 28th day. Results: NAS score at first hour and 24th hour was significantly reduced (P = 0.001), after each infusion [7th, 14th day] in both the groups. There was no statistical difference in pain score among both groups except for day 7 (P value 0.04). Reduction in NAS score was also present on 21st and 28th day in both groups, but it did not reach a significant value. On 28th day, NAS score values showed increasing trend. Duration of pain relief was around 1 week after each infusion in both groups. Conclusion: Intravenous lidocaine at a dose of 3 mg/kg or 4 mg/kg was effective in reducing pain in patients with chronic pain. The analgesic effect was not different among both groups. Trend of greater response was observed with 4 mg/kg dose.http://www.mamcjms.in/article.asp?issn=2394-7438;year=2023;volume=9;issue=1;spage=13;epage=17;aulast=Ghaichronic neuropathic painintravenous lidocainenumeric analog scale [nas] |
| spellingShingle | Anju Ghai Bharti Verma Kanika Rohilla Evaluation of Efficacy of Two Different Doses of Intravenous Lidocaine in Patients with Chronic Pain MAMC Journal of Medical Sciences chronic neuropathic pain intravenous lidocaine numeric analog scale [nas] |
| title | Evaluation of Efficacy of Two Different Doses of Intravenous Lidocaine in Patients with Chronic Pain |
| title_full | Evaluation of Efficacy of Two Different Doses of Intravenous Lidocaine in Patients with Chronic Pain |
| title_fullStr | Evaluation of Efficacy of Two Different Doses of Intravenous Lidocaine in Patients with Chronic Pain |
| title_full_unstemmed | Evaluation of Efficacy of Two Different Doses of Intravenous Lidocaine in Patients with Chronic Pain |
| title_short | Evaluation of Efficacy of Two Different Doses of Intravenous Lidocaine in Patients with Chronic Pain |
| title_sort | evaluation of efficacy of two different doses of intravenous lidocaine in patients with chronic pain |
| topic | chronic neuropathic pain intravenous lidocaine numeric analog scale [nas] |
| url | http://www.mamcjms.in/article.asp?issn=2394-7438;year=2023;volume=9;issue=1;spage=13;epage=17;aulast=Ghai |
| work_keys_str_mv | AT anjughai evaluationofefficacyoftwodifferentdosesofintravenouslidocaineinpatientswithchronicpain AT bhartiverma evaluationofefficacyoftwodifferentdosesofintravenouslidocaineinpatientswithchronicpain AT kanikarohilla evaluationofefficacyoftwodifferentdosesofintravenouslidocaineinpatientswithchronicpain |