A European International Multicentre Survey on the Current Practice of Perioperative Antibiotic Prophylaxis for Paediatric Liver Transplantations
(1) Background: Postoperative infections are major contributors of morbidity and mortality after paediatric liver transplantation (pLTX). Evidence and recommendations regarding the most effective antimicrobial strategy are lacking. (2) Results: Of 39 pLTX centres, 20 responded. Aminopenicillins plus...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/2/292 |
| _version_ | 1797622780456337408 |
|---|---|
| author | Juliane Hauschild Nora Bruns Elke Lainka Christian Dohna-Schwake |
| author_facet | Juliane Hauschild Nora Bruns Elke Lainka Christian Dohna-Schwake |
| author_sort | Juliane Hauschild |
| collection | DOAJ |
| description | (1) Background: Postoperative infections are major contributors of morbidity and mortality after paediatric liver transplantation (pLTX). Evidence and recommendations regarding the most effective antimicrobial strategy are lacking. (2) Results: Of 39 pLTX centres, 20 responded. Aminopenicillins plus ß-lactamase inhibitors were used by six (30%) and third generation cephalosporins by three (15%), with the remaining centres reporting heterogenous regimens. Broad-spectrum regimens were the standard in 10 (50%) of centres and less frequent in the 16 (80%) centres with an infectious disease specialist. The duration ranged mainly between 24–48 h and 3–5 days in the absence and 3–5 days or 6–10 days in the presence of risk factors. Strategies regarding antifungal, antiviral, adjunctive antimicrobial, and surveillance strategies varied widely. (3) Methods: This international multicentre survey endorsed by the European Liver Transplant Registry queried all European pLTX centres from the registry on their current practice of perioperative antibiotic prophylaxis and antimicrobial strategies via an online questionnaire. (4) Conclusions: This survey found great heterogeneity regarding all aspects of postoperative antimicrobial treatment, surveillance, and prevention of infections in European pLTX centres. Evidence-based recommendations are urgently needed to optimise antimicrobial strategies and reduce the spectrum and duration of antimicrobial exposure. |
| first_indexed | 2024-03-11T09:15:07Z |
| format | Article |
| id | doaj.art-82dc98f973d44070ba066acde92440e2 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T09:15:07Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-82dc98f973d44070ba066acde92440e22023-11-16T18:42:55ZengMDPI AGAntibiotics2079-63822023-02-0112229210.3390/antibiotics12020292A European International Multicentre Survey on the Current Practice of Perioperative Antibiotic Prophylaxis for Paediatric Liver TransplantationsJuliane Hauschild0Nora Bruns1Elke Lainka2Christian Dohna-Schwake3Department of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, GermanyDepartment of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, GermanyDepartment of Paediatrics II, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, GermanyDepartment of Paediatrics I, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany(1) Background: Postoperative infections are major contributors of morbidity and mortality after paediatric liver transplantation (pLTX). Evidence and recommendations regarding the most effective antimicrobial strategy are lacking. (2) Results: Of 39 pLTX centres, 20 responded. Aminopenicillins plus ß-lactamase inhibitors were used by six (30%) and third generation cephalosporins by three (15%), with the remaining centres reporting heterogenous regimens. Broad-spectrum regimens were the standard in 10 (50%) of centres and less frequent in the 16 (80%) centres with an infectious disease specialist. The duration ranged mainly between 24–48 h and 3–5 days in the absence and 3–5 days or 6–10 days in the presence of risk factors. Strategies regarding antifungal, antiviral, adjunctive antimicrobial, and surveillance strategies varied widely. (3) Methods: This international multicentre survey endorsed by the European Liver Transplant Registry queried all European pLTX centres from the registry on their current practice of perioperative antibiotic prophylaxis and antimicrobial strategies via an online questionnaire. (4) Conclusions: This survey found great heterogeneity regarding all aspects of postoperative antimicrobial treatment, surveillance, and prevention of infections in European pLTX centres. Evidence-based recommendations are urgently needed to optimise antimicrobial strategies and reduce the spectrum and duration of antimicrobial exposure.https://www.mdpi.com/2079-6382/12/2/292paediatric liver transplantationperioperative prophylaxisantibioticsantibiotic exposureantimicrobialsinfectious disease specialist |
| spellingShingle | Juliane Hauschild Nora Bruns Elke Lainka Christian Dohna-Schwake A European International Multicentre Survey on the Current Practice of Perioperative Antibiotic Prophylaxis for Paediatric Liver Transplantations Antibiotics paediatric liver transplantation perioperative prophylaxis antibiotics antibiotic exposure antimicrobials infectious disease specialist |
| title | A European International Multicentre Survey on the Current Practice of Perioperative Antibiotic Prophylaxis for Paediatric Liver Transplantations |
| title_full | A European International Multicentre Survey on the Current Practice of Perioperative Antibiotic Prophylaxis for Paediatric Liver Transplantations |
| title_fullStr | A European International Multicentre Survey on the Current Practice of Perioperative Antibiotic Prophylaxis for Paediatric Liver Transplantations |
| title_full_unstemmed | A European International Multicentre Survey on the Current Practice of Perioperative Antibiotic Prophylaxis for Paediatric Liver Transplantations |
| title_short | A European International Multicentre Survey on the Current Practice of Perioperative Antibiotic Prophylaxis for Paediatric Liver Transplantations |
| title_sort | european international multicentre survey on the current practice of perioperative antibiotic prophylaxis for paediatric liver transplantations |
| topic | paediatric liver transplantation perioperative prophylaxis antibiotics antibiotic exposure antimicrobials infectious disease specialist |
| url | https://www.mdpi.com/2079-6382/12/2/292 |
| work_keys_str_mv | AT julianehauschild aeuropeaninternationalmulticentresurveyonthecurrentpracticeofperioperativeantibioticprophylaxisforpaediatriclivertransplantations AT norabruns aeuropeaninternationalmulticentresurveyonthecurrentpracticeofperioperativeantibioticprophylaxisforpaediatriclivertransplantations AT elkelainka aeuropeaninternationalmulticentresurveyonthecurrentpracticeofperioperativeantibioticprophylaxisforpaediatriclivertransplantations AT christiandohnaschwake aeuropeaninternationalmulticentresurveyonthecurrentpracticeofperioperativeantibioticprophylaxisforpaediatriclivertransplantations AT julianehauschild europeaninternationalmulticentresurveyonthecurrentpracticeofperioperativeantibioticprophylaxisforpaediatriclivertransplantations AT norabruns europeaninternationalmulticentresurveyonthecurrentpracticeofperioperativeantibioticprophylaxisforpaediatriclivertransplantations AT elkelainka europeaninternationalmulticentresurveyonthecurrentpracticeofperioperativeantibioticprophylaxisforpaediatriclivertransplantations AT christiandohnaschwake europeaninternationalmulticentresurveyonthecurrentpracticeofperioperativeantibioticprophylaxisforpaediatriclivertransplantations |