Accelerated loss of trunk muscle density and size at L1 vertebral level in male patients with COPD
Background and purposeWeight loss and muscle mass loss are common in patients with chronic obstructive pulmonary disease (COPD). Muscle density and fat infiltration based on CT images may be more sensitive than muscle mass by DXA in the assessment of sarcopenia for COPD patients. However, the age-re...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1087110/full |
| _version_ | 1811290905844383744 |
|---|---|
| author | Ying Wang Ying Wang Sidong Li Zhenyi Zhang Zhenyi Zhang Shiqi Sun Juntao Feng Juntao Feng Jinbiao Chen Yigang Pei Yigang Pei Xianjing Peng Xianjing Peng |
| author_facet | Ying Wang Ying Wang Sidong Li Zhenyi Zhang Zhenyi Zhang Shiqi Sun Juntao Feng Juntao Feng Jinbiao Chen Yigang Pei Yigang Pei Xianjing Peng Xianjing Peng |
| author_sort | Ying Wang |
| collection | DOAJ |
| description | Background and purposeWeight loss and muscle mass loss are common in patients with chronic obstructive pulmonary disease (COPD). Muscle density and fat infiltration based on CT images may be more sensitive than muscle mass by DXA in the assessment of sarcopenia for COPD patients. However, the age-related changes of cross-sectional trunk muscle compositions based on lung CT scans are still unknown. Thus, we aimed to investigate over time the change in muscle density, size, and fat deposition of L1-level trunk muscles in patients with COPD.Materials and methods129 male COPD patients with a second chest CT scan (from 2013-2019 to 2014-2020) were enrolled. The CT images at first and second CT scans are analyzed by OsiriX software. Trunk muscles at the level of the 1st lumbar vertebrae were selected for analysis. Attenuation of lumbar vertebrae 1 was also measured from chest CT images. The pulmonary function values were calculated based on forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC).ResultsThe mean age of the 129 patients with COPD was 69.7 years. The durations of COPD of this cohort were from 8-17 years. The mean area and density of L1 trunk muscles were 85.5 cm2 and 36.4 HU. At baseline, muscle area and density and vertebral density were negatively associated with age (p<0.0001), while the intermuscular fat area and the fat infiltration ratio were not significantly associated with age (p>0.05). The per-year loss of trunk muscle area was 2.83 cm2 (p<0.0001) which accounts for 3.3% decrease per year, and the per-year decrease of trunk muscle density was 2.41 HU (p<0.0001) which accounts for 6.6% decrease per year. The per-year increase of intermuscular fat in trunk muscles was 0.57 cm2 (p=0.006) which accounts for 11.1% increase per year. The bone density loss was 5.63 HU/per year (p<0.0001).ConclusionMen with COPD had accelerated muscle loss as well as increased fat infiltration. Compared to muscle quantity loss, the decline in muscle quality is much larger, indicating the importance of relevant interventions focusing on improving muscle quality. |
| first_indexed | 2024-04-13T04:21:24Z |
| format | Article |
| id | doaj.art-82dda44fc577450f92016825b65aeaeb |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T04:21:24Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-82dda44fc577450f92016825b65aeaeb2022-12-22T03:02:46ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.10871101087110Accelerated loss of trunk muscle density and size at L1 vertebral level in male patients with COPDYing Wang0Ying Wang1Sidong Li2Zhenyi Zhang3Zhenyi Zhang4Shiqi Sun5Juntao Feng6Juntao Feng7Jinbiao Chen8Yigang Pei9Yigang Pei10Xianjing Peng11Xianjing Peng12Department of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Radiology, Taojiang County People’s Hospital, Yiyang, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Medical Records & Information, Central South University, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, ChinaBackground and purposeWeight loss and muscle mass loss are common in patients with chronic obstructive pulmonary disease (COPD). Muscle density and fat infiltration based on CT images may be more sensitive than muscle mass by DXA in the assessment of sarcopenia for COPD patients. However, the age-related changes of cross-sectional trunk muscle compositions based on lung CT scans are still unknown. Thus, we aimed to investigate over time the change in muscle density, size, and fat deposition of L1-level trunk muscles in patients with COPD.Materials and methods129 male COPD patients with a second chest CT scan (from 2013-2019 to 2014-2020) were enrolled. The CT images at first and second CT scans are analyzed by OsiriX software. Trunk muscles at the level of the 1st lumbar vertebrae were selected for analysis. Attenuation of lumbar vertebrae 1 was also measured from chest CT images. The pulmonary function values were calculated based on forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC).ResultsThe mean age of the 129 patients with COPD was 69.7 years. The durations of COPD of this cohort were from 8-17 years. The mean area and density of L1 trunk muscles were 85.5 cm2 and 36.4 HU. At baseline, muscle area and density and vertebral density were negatively associated with age (p<0.0001), while the intermuscular fat area and the fat infiltration ratio were not significantly associated with age (p>0.05). The per-year loss of trunk muscle area was 2.83 cm2 (p<0.0001) which accounts for 3.3% decrease per year, and the per-year decrease of trunk muscle density was 2.41 HU (p<0.0001) which accounts for 6.6% decrease per year. The per-year increase of intermuscular fat in trunk muscles was 0.57 cm2 (p=0.006) which accounts for 11.1% increase per year. The bone density loss was 5.63 HU/per year (p<0.0001).ConclusionMen with COPD had accelerated muscle loss as well as increased fat infiltration. Compared to muscle quantity loss, the decline in muscle quality is much larger, indicating the importance of relevant interventions focusing on improving muscle quality.https://www.frontiersin.org/articles/10.3389/fendo.2022.1087110/fullchronic obstructive pulmonary diseaseL1-trunk musclemuscle sizemuscle densitychange |
| spellingShingle | Ying Wang Ying Wang Sidong Li Zhenyi Zhang Zhenyi Zhang Shiqi Sun Juntao Feng Juntao Feng Jinbiao Chen Yigang Pei Yigang Pei Xianjing Peng Xianjing Peng Accelerated loss of trunk muscle density and size at L1 vertebral level in male patients with COPD Frontiers in Endocrinology chronic obstructive pulmonary disease L1-trunk muscle muscle size muscle density change |
| title | Accelerated loss of trunk muscle density and size at L1 vertebral level in male patients with COPD |
| title_full | Accelerated loss of trunk muscle density and size at L1 vertebral level in male patients with COPD |
| title_fullStr | Accelerated loss of trunk muscle density and size at L1 vertebral level in male patients with COPD |
| title_full_unstemmed | Accelerated loss of trunk muscle density and size at L1 vertebral level in male patients with COPD |
| title_short | Accelerated loss of trunk muscle density and size at L1 vertebral level in male patients with COPD |
| title_sort | accelerated loss of trunk muscle density and size at l1 vertebral level in male patients with copd |
| topic | chronic obstructive pulmonary disease L1-trunk muscle muscle size muscle density change |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1087110/full |
| work_keys_str_mv | AT yingwang acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd AT yingwang acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd AT sidongli acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd AT zhenyizhang acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd AT zhenyizhang acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd AT shiqisun acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd AT juntaofeng acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd AT juntaofeng acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd AT jinbiaochen acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd AT yigangpei acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd AT yigangpei acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd AT xianjingpeng acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd AT xianjingpeng acceleratedlossoftrunkmuscledensityandsizeatl1vertebrallevelinmalepatientswithcopd |