Early-life stress induces persistent alterationsin 5-HT1Areceptor and serotonin transporter mRNA expression in the adultrat brain.

Early-life stress induces persistent alterationsin 5-HT1Areceptor and serotonin transporter mRNA expression in the adultrat brain.

Early-life experience plays a major role in the stress response throughout life. Neonatal maternal separation (MS) is an animal model of depression with an altered serotonergic response. We hypothesize that this alteration may be caused by differences in 5-HT1A receptor and serotonin transporter (SE...

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Bibliographic Details
Main Authors: Javier A. Bravo, Timothy G. Dinan, John F. Cryan
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Amygdala
dorsal raphe nucleus
maternal separation
serotonin transporter
5-HT1A receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00024/full

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