To the question of the pathogenesis of endometrial hyperplasia
Traditional attitude towards the role of hyperestrogenia in endometrial hyperplasia pathogenesis can be considered cogent only in case of simple endometrial hyperplasia (SEH). In case of complex endometrial hyperplasia (CEH) and atypical endometrial hyperplasia (AEH) excessive proliferation occurs o...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-07-01
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| Series: | Опухоли женской репродуктивной системы |
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| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/124 |
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| author | A. Kh. Bishtavi O. A. Gornikh V. N. Gulieva N. G. Chikovani Kh. T. Gogoladze A. Yu. Kostin A. Yе. Ivanov A. M. Chabrov A. G. Solopova Yu. Yu. Tabakman I. B. Manukhin |
| author_facet | A. Kh. Bishtavi O. A. Gornikh V. N. Gulieva N. G. Chikovani Kh. T. Gogoladze A. Yu. Kostin A. Yе. Ivanov A. M. Chabrov A. G. Solopova Yu. Yu. Tabakman I. B. Manukhin |
| author_sort | A. Kh. Bishtavi |
| collection | DOAJ |
| description | Traditional attitude towards the role of hyperestrogenia in endometrial hyperplasia pathogenesis can be considered cogent only in case of simple endometrial hyperplasia (SEH). In case of complex endometrial hyperplasia (CEH) and atypical endometrial hyperplasia (AEH) excessive proliferation occurs only in endometrial glands not diffusely but as pockets. The signs of atrophy are often registered outside these pockets that reflects the state of estrogens.The aim: is to study the structure of pathological endometrial changes that patients with abnormal uterine bleeding (AUB) have and natural combination of various forms of pathological endometrial changes.Material. The results of histological examination of endometrium collected from 668 patients have been studied.Results. The structure of pathological changes that occur in case of AUB has been identified. Various endometrial changes outside CEH and AEH pockets against the background of SEH, polyposis, atrophic endometrium have been detected without any regularity; the fact that does not confirm the role of hyperestrogenia in CEH and AEH pathogenesis.Conclusion. SEH being the result of estrogen and progesterone imbalance is subjected to cyclic progestin hormone therapy to prevent acyclic bleeding. Observation with regular control is acceptable in the absence of AUB after the curettage in case of SEH and CEH without atypia. In case of AEH surgical treatment is required. |
| first_indexed | 2024-04-10T01:57:41Z |
| format | Article |
| id | doaj.art-82de80aafc604590952054c12fbf71db |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2025-03-14T08:27:08Z |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-82de80aafc604590952054c12fbf71db2025-03-02T13:05:29ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-07-0103-410811110.17650/1994-4098-2012-0-3-4-108-111140To the question of the pathogenesis of endometrial hyperplasiaA. Kh. Bishtavi0O. A. Gornikh1V. N. Gulieva2N. G. Chikovani3Kh. T. Gogoladze4A. Yu. Kostin5A. Yе. Ivanov6A. M. Chabrov7A. G. Solopova8Yu. Yu. Tabakman9I. B. Manukhin10Department of Oncology, Moscow State University of Medicine and DentistryDepartment of Oncology, Moscow State University of Medicine and DentistryI.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaI.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaI.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaCancer Clinic No 1 Department of Health in MoscowCancer Clinic No 1 Department of Health in MoscowCancer Clinic No 1 Department of Health in MoscowI.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaCancer Clinic No 1 Department of Health in MoscowDepartment of Oncology, Moscow State University of Medicine and DentistryTraditional attitude towards the role of hyperestrogenia in endometrial hyperplasia pathogenesis can be considered cogent only in case of simple endometrial hyperplasia (SEH). In case of complex endometrial hyperplasia (CEH) and atypical endometrial hyperplasia (AEH) excessive proliferation occurs only in endometrial glands not diffusely but as pockets. The signs of atrophy are often registered outside these pockets that reflects the state of estrogens.The aim: is to study the structure of pathological endometrial changes that patients with abnormal uterine bleeding (AUB) have and natural combination of various forms of pathological endometrial changes.Material. The results of histological examination of endometrium collected from 668 patients have been studied.Results. The structure of pathological changes that occur in case of AUB has been identified. Various endometrial changes outside CEH and AEH pockets against the background of SEH, polyposis, atrophic endometrium have been detected without any regularity; the fact that does not confirm the role of hyperestrogenia in CEH and AEH pathogenesis.Conclusion. SEH being the result of estrogen and progesterone imbalance is subjected to cyclic progestin hormone therapy to prevent acyclic bleeding. Observation with regular control is acceptable in the absence of AUB after the curettage in case of SEH and CEH without atypia. In case of AEH surgical treatment is required.https://ojrs.abvpress.ru/ojrs/article/view/124endometrial hyperplasiapathogenesistreatment strategy |
| spellingShingle | A. Kh. Bishtavi O. A. Gornikh V. N. Gulieva N. G. Chikovani Kh. T. Gogoladze A. Yu. Kostin A. Yе. Ivanov A. M. Chabrov A. G. Solopova Yu. Yu. Tabakman I. B. Manukhin To the question of the pathogenesis of endometrial hyperplasia Опухоли женской репродуктивной системы endometrial hyperplasia pathogenesis treatment strategy |
| title | To the question of the pathogenesis of endometrial hyperplasia |
| title_full | To the question of the pathogenesis of endometrial hyperplasia |
| title_fullStr | To the question of the pathogenesis of endometrial hyperplasia |
| title_full_unstemmed | To the question of the pathogenesis of endometrial hyperplasia |
| title_short | To the question of the pathogenesis of endometrial hyperplasia |
| title_sort | to the question of the pathogenesis of endometrial hyperplasia |
| topic | endometrial hyperplasia pathogenesis treatment strategy |
| url | https://ojrs.abvpress.ru/ojrs/article/view/124 |
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