Sleep Duration in Mouse Models of Neurodevelopmental Disorders
Sleep abnormalities are common in patients with neurodevelopmental disorders, and it is thought that deficits in sleep may contribute to the unfolding of symptoms in these disorders. Appreciating sleep abnormalities in neurodevelopmental disorders could be important for designing a treatment for the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/1/31 |
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| author | Rachel Michelle Saré Abigail Lemons Alex Song Carolyn Beebe Smith |
| author_facet | Rachel Michelle Saré Abigail Lemons Alex Song Carolyn Beebe Smith |
| author_sort | Rachel Michelle Saré |
| collection | DOAJ |
| description | Sleep abnormalities are common in patients with neurodevelopmental disorders, and it is thought that deficits in sleep may contribute to the unfolding of symptoms in these disorders. Appreciating sleep abnormalities in neurodevelopmental disorders could be important for designing a treatment for these disorders. We studied sleep duration in three mouse models by means of home-cage monitoring: <i>Tsc2</i><sup>+/−</sup> (tuberous sclerosis complex), oxytocin receptor (<i>Oxtr</i>) knockout (KO) (autism spectrum disorders), and <i>Shank3 <sup>e4-9</sup></i> KO (Phelan–McDermid syndrome). We studied both male and female mice, and data were analyzed to examine effects of both genotype and sex. In general, we found that female mice slept less than males regardless of genotype or phase. We did not find any differences in sleep duration in either <i>Tsc2</i><sup>+/−</sup> or <i>Oxtr</i> KO mice, compared to controls. In <i>Shank3 <sup>e4-9</sup></i> KO mice, we found a statistically significant genotype x phase interaction (<i>p</i> = 0.002) with a trend that <i>Shank3</i><i><sup>e4-9</sup></i> KO mice regardless of sex slept more than control mice in the active phase. Our results have implications for the management of patients with Phelan–McDermid syndrome. |
| first_indexed | 2024-03-10T13:39:47Z |
| format | Article |
| id | doaj.art-82df0c1f83f04be197ad48f208371af0 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T13:39:47Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-82df0c1f83f04be197ad48f208371af02023-11-21T03:06:46ZengMDPI AGBrain Sciences2076-34252020-12-011113110.3390/brainsci11010031Sleep Duration in Mouse Models of Neurodevelopmental DisordersRachel Michelle Saré0Abigail Lemons1Alex Song2Carolyn Beebe Smith3Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Section on Neuroadaptation and Protein Metabolism, Bethesda, MD 20814, USADepartment of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Section on Neuroadaptation and Protein Metabolism, Bethesda, MD 20814, USADepartment of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Section on Neuroadaptation and Protein Metabolism, Bethesda, MD 20814, USADepartment of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Section on Neuroadaptation and Protein Metabolism, Bethesda, MD 20814, USASleep abnormalities are common in patients with neurodevelopmental disorders, and it is thought that deficits in sleep may contribute to the unfolding of symptoms in these disorders. Appreciating sleep abnormalities in neurodevelopmental disorders could be important for designing a treatment for these disorders. We studied sleep duration in three mouse models by means of home-cage monitoring: <i>Tsc2</i><sup>+/−</sup> (tuberous sclerosis complex), oxytocin receptor (<i>Oxtr</i>) knockout (KO) (autism spectrum disorders), and <i>Shank3 <sup>e4-9</sup></i> KO (Phelan–McDermid syndrome). We studied both male and female mice, and data were analyzed to examine effects of both genotype and sex. In general, we found that female mice slept less than males regardless of genotype or phase. We did not find any differences in sleep duration in either <i>Tsc2</i><sup>+/−</sup> or <i>Oxtr</i> KO mice, compared to controls. In <i>Shank3 <sup>e4-9</sup></i> KO mice, we found a statistically significant genotype x phase interaction (<i>p</i> = 0.002) with a trend that <i>Shank3</i><i><sup>e4-9</sup></i> KO mice regardless of sex slept more than control mice in the active phase. Our results have implications for the management of patients with Phelan–McDermid syndrome.https://www.mdpi.com/2076-3425/11/1/31neurodevelopmental disorderssleep durationPhelan–McDermid syndromeShank3oxytocin receptortuberous sclerosis |
| spellingShingle | Rachel Michelle Saré Abigail Lemons Alex Song Carolyn Beebe Smith Sleep Duration in Mouse Models of Neurodevelopmental Disorders Brain Sciences neurodevelopmental disorders sleep duration Phelan–McDermid syndrome Shank3 oxytocin receptor tuberous sclerosis |
| title | Sleep Duration in Mouse Models of Neurodevelopmental Disorders |
| title_full | Sleep Duration in Mouse Models of Neurodevelopmental Disorders |
| title_fullStr | Sleep Duration in Mouse Models of Neurodevelopmental Disorders |
| title_full_unstemmed | Sleep Duration in Mouse Models of Neurodevelopmental Disorders |
| title_short | Sleep Duration in Mouse Models of Neurodevelopmental Disorders |
| title_sort | sleep duration in mouse models of neurodevelopmental disorders |
| topic | neurodevelopmental disorders sleep duration Phelan–McDermid syndrome Shank3 oxytocin receptor tuberous sclerosis |
| url | https://www.mdpi.com/2076-3425/11/1/31 |
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