Mitochondrial Lipid Peroxidation Is Responsible for Ferroptosis

Mitochondrial Lipid Peroxidation Is Responsible for Ferroptosis

Ferroptosis induced by erastin (an inhibitor of cystine transport) and butionine sulfoximine (an inhibitor of glutathione biosynthesis) was prevented by the mitochondria-targeted antioxidants SkQ1 and MitoTEMPO. These effects correlate with the prevention of mitochondrial lipid peroxidation, which p...

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Bibliographic Details
Main Authors: Konstantin G. Lyamzaev, Alisa A. Panteleeva, Ruben A. Simonyan, Armine V. Avetisyan, Boris V. Chernyak
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cells
Subjects:
ferroptosis
mitochondria
complex I
mtROS
mitochondria targeted antioxidants
Online Access:https://www.mdpi.com/2073-4409/12/4/611

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