TCR-signaling events in cellular metabolism and specialization

TCR-signaling events in cellular metabolism and specialization

Engaging the T cell receptor (TCR) with peptide:MHC complexes initiates a cascade of signaling events that activates T cells in an antigen specific manner. It is now clear that multiple inputs, including the strength of TCR signaling, co-stimulation, and the cytokine environment, impact T cell spec...

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Bibliographic Details
Main Authors: Danielle A. Chisolm, Amy S. Weinmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Immunology
Subjects:
Cytokines
Metabolism
T cells
HIF-1alpha
IRF4
TCR signaling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00292/full

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