KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels

KUS121, a VCP modulator, has an ameliorating effect on acute and chronic heart failure without calcium loading via maintenance of intracellular ATP levels

Aims: As heart failure (HF) progresses, ATP levels in myocardial cells decrease, and myocardial contractility also decreases. Inotropic drugs improve myocardial contractility but increase ATP consumption, leading to poor prognosis. Kyoto University Substance 121 (KUS121) is known to selectively inhi...

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Bibliographic Details
Main Authors: Shuhei Tsuji, Chiharu Otani, Takahiro Horie, Shin Watanabe, Osamu Baba, Naoya Sowa, Yuya Ide, Asami Kashiwa, Takeru Makiyama, Hirohiko Imai, Yasuhiro Nakashima, Tomohiro Yamasaki, Sijia Xu, Kazuki Matsushita, Keita Suzuki, Fuquan Zou, Eitaro Kume, Koji Hasegawa, Takeshi Kimura, Akira Kakizuka, Koh Ono
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Heart failure
ATP
KUS121
Therapeutic agent
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016487

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http://www.sciencedirect.com/science/article/pii/S0753332223016487

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