Effect of the Enantiomeric Ratio of Eutectics on the Results and Products of the Reactions Proceeding with the Participation of Enantiomers and Enantiomeric Mixtures
This perspective is focused on the main parameters determining the results of crystallization of enantiomers or enantiomeric mixtures. It was shown that the ratio of supramolecular and helical associations depends on the eutectic composition of the corresponding enantiomeric mixture. The M and P rat...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
|
| Series: | Chemistry |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2624-8549/2/3/51 |
| _version_ | 1797553109350744064 |
|---|---|
| author | Emese Pálovics Dorottya Fruzsina Bánhegyi Elemér Fogassy |
| author_facet | Emese Pálovics Dorottya Fruzsina Bánhegyi Elemér Fogassy |
| author_sort | Emese Pálovics |
| collection | DOAJ |
| description | This perspective is focused on the main parameters determining the results of crystallization of enantiomers or enantiomeric mixtures. It was shown that the ratio of supramolecular and helical associations depends on the eutectic composition of the corresponding enantiomeric mixture. The M and P ratios together with the self-disproportionation (SDE) of enantiomers define the reaction of the racemic compound with the resolving agent. Eventually, each chiral molecule reacts with at least two conformers with different degrees of M and P helicity. The combined effect of the configuration, charge distribution, constituent atoms, bonds, flexibility, and asymmetry of the molecules influencing their behavior was also summarized. |
| first_indexed | 2024-03-10T16:11:42Z |
| format | Article |
| id | doaj.art-82e32df1a3a44507ac3327436149a6b4 |
| institution | Directory Open Access Journal |
| issn | 2624-8549 |
| language | English |
| last_indexed | 2024-03-10T16:11:42Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry |
| spelling | doaj.art-82e32df1a3a44507ac3327436149a6b42023-11-20T14:26:54ZengMDPI AGChemistry2624-85492020-09-012378779510.3390/chemistry2030051Effect of the Enantiomeric Ratio of Eutectics on the Results and Products of the Reactions Proceeding with the Participation of Enantiomers and Enantiomeric MixturesEmese Pálovics0Dorottya Fruzsina Bánhegyi1Elemér Fogassy2Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, HungaryThis perspective is focused on the main parameters determining the results of crystallization of enantiomers or enantiomeric mixtures. It was shown that the ratio of supramolecular and helical associations depends on the eutectic composition of the corresponding enantiomeric mixture. The M and P ratios together with the self-disproportionation (SDE) of enantiomers define the reaction of the racemic compound with the resolving agent. Eventually, each chiral molecule reacts with at least two conformers with different degrees of M and P helicity. The combined effect of the configuration, charge distribution, constituent atoms, bonds, flexibility, and asymmetry of the molecules influencing their behavior was also summarized.https://www.mdpi.com/2624-8549/2/3/51chiral moleculesenantiomeric separationself-disproportionation of enantiomerssupramolecular associationshelical structureeutectic composition |
| spellingShingle | Emese Pálovics Dorottya Fruzsina Bánhegyi Elemér Fogassy Effect of the Enantiomeric Ratio of Eutectics on the Results and Products of the Reactions Proceeding with the Participation of Enantiomers and Enantiomeric Mixtures Chemistry chiral molecules enantiomeric separation self-disproportionation of enantiomers supramolecular associations helical structure eutectic composition |
| title | Effect of the Enantiomeric Ratio of Eutectics on the Results and Products of the Reactions Proceeding with the Participation of Enantiomers and Enantiomeric Mixtures |
| title_full | Effect of the Enantiomeric Ratio of Eutectics on the Results and Products of the Reactions Proceeding with the Participation of Enantiomers and Enantiomeric Mixtures |
| title_fullStr | Effect of the Enantiomeric Ratio of Eutectics on the Results and Products of the Reactions Proceeding with the Participation of Enantiomers and Enantiomeric Mixtures |
| title_full_unstemmed | Effect of the Enantiomeric Ratio of Eutectics on the Results and Products of the Reactions Proceeding with the Participation of Enantiomers and Enantiomeric Mixtures |
| title_short | Effect of the Enantiomeric Ratio of Eutectics on the Results and Products of the Reactions Proceeding with the Participation of Enantiomers and Enantiomeric Mixtures |
| title_sort | effect of the enantiomeric ratio of eutectics on the results and products of the reactions proceeding with the participation of enantiomers and enantiomeric mixtures |
| topic | chiral molecules enantiomeric separation self-disproportionation of enantiomers supramolecular associations helical structure eutectic composition |
| url | https://www.mdpi.com/2624-8549/2/3/51 |
| work_keys_str_mv | AT emesepalovics effectoftheenantiomericratioofeutecticsontheresultsandproductsofthereactionsproceedingwiththeparticipationofenantiomersandenantiomericmixtures AT dorottyafruzsinabanhegyi effectoftheenantiomericratioofeutecticsontheresultsandproductsofthereactionsproceedingwiththeparticipationofenantiomersandenantiomericmixtures AT elemerfogassy effectoftheenantiomericratioofeutecticsontheresultsandproductsofthereactionsproceedingwiththeparticipationofenantiomersandenantiomericmixtures |