Harnessing Cyanobacteria’s Bioactive Potential: A Sustainable Strategy for Antioxidant Production
Unsaturated diacylglycerols are a class of antioxidant compounds with the potential to positively impact human health. Their ability to combat oxidative stress through radical scavenger activity underscores their significance in the context of preventive and therapeutic strategies. In this paper we...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/1/175 |
| _version_ | 1797339620875173888 |
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| author | Teresa De Rosa Maria Ponticelli Roberta Teta Vittorio Carlucci Luigi Milella Germana Esposito Valeria Costantino |
| author_facet | Teresa De Rosa Maria Ponticelli Roberta Teta Vittorio Carlucci Luigi Milella Germana Esposito Valeria Costantino |
| author_sort | Teresa De Rosa |
| collection | DOAJ |
| description | Unsaturated diacylglycerols are a class of antioxidant compounds with the potential to positively impact human health. Their ability to combat oxidative stress through radical scavenger activity underscores their significance in the context of preventive and therapeutic strategies. In this paper we highlight the role of <i>Anabaena flos-aquae</i> as a producer of unsaturated mono and diacylglycerols, and then demonstrate the antioxidant activity of its methanolic extract, which has as its main components a variety of acylglycerol analogues. This finding was revealed using a sustainable strategy in which the One Strain Many Compounds (OSMAC) cultivation in microscale was coupled with a bioinformatic approach to analyze a large dataset of mass spectrometry data using the molecular networking analyses. This strategy reduces time and costs, avoiding long and expensive steps of purification and obtaining informative data on the metabolic composition of the extracts. This study highlights the role of <i>Anabaena</i> as a sustainable and green source of novel bioactive compounds. |
| first_indexed | 2024-03-08T09:49:47Z |
| format | Article |
| id | doaj.art-82e71e7dddb64e2bb3ae41c8511ac3e4 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-08T09:49:47Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-82e71e7dddb64e2bb3ae41c8511ac3e42024-01-29T14:06:47ZengMDPI AGMicroorganisms2076-26072024-01-0112117510.3390/microorganisms12010175Harnessing Cyanobacteria’s Bioactive Potential: A Sustainable Strategy for Antioxidant ProductionTeresa De Rosa0Maria Ponticelli1Roberta Teta2Vittorio Carlucci3Luigi Milella4Germana Esposito5Valeria Costantino6The Blue Chemistry Lab, Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, ItalyDepartment of Science, Università Degli Studi Della Basilicata, V.le dell’Ateneo Lucano 10, 85100 Potenza, ItalyThe Blue Chemistry Lab, Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, ItalyDepartment of Science, Università Degli Studi Della Basilicata, V.le dell’Ateneo Lucano 10, 85100 Potenza, ItalyDepartment of Science, Università Degli Studi Della Basilicata, V.le dell’Ateneo Lucano 10, 85100 Potenza, ItalyThe Blue Chemistry Lab, Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, ItalyThe Blue Chemistry Lab, Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, ItalyUnsaturated diacylglycerols are a class of antioxidant compounds with the potential to positively impact human health. Their ability to combat oxidative stress through radical scavenger activity underscores their significance in the context of preventive and therapeutic strategies. In this paper we highlight the role of <i>Anabaena flos-aquae</i> as a producer of unsaturated mono and diacylglycerols, and then demonstrate the antioxidant activity of its methanolic extract, which has as its main components a variety of acylglycerol analogues. This finding was revealed using a sustainable strategy in which the One Strain Many Compounds (OSMAC) cultivation in microscale was coupled with a bioinformatic approach to analyze a large dataset of mass spectrometry data using the molecular networking analyses. This strategy reduces time and costs, avoiding long and expensive steps of purification and obtaining informative data on the metabolic composition of the extracts. This study highlights the role of <i>Anabaena</i> as a sustainable and green source of novel bioactive compounds.https://www.mdpi.com/2076-2607/12/1/175cyanobacteria<i>Anabaena</i>natural productsmass spectrometrymolecular networkantioxidant |
| spellingShingle | Teresa De Rosa Maria Ponticelli Roberta Teta Vittorio Carlucci Luigi Milella Germana Esposito Valeria Costantino Harnessing Cyanobacteria’s Bioactive Potential: A Sustainable Strategy for Antioxidant Production Microorganisms cyanobacteria <i>Anabaena</i> natural products mass spectrometry molecular network antioxidant |
| title | Harnessing Cyanobacteria’s Bioactive Potential: A Sustainable Strategy for Antioxidant Production |
| title_full | Harnessing Cyanobacteria’s Bioactive Potential: A Sustainable Strategy for Antioxidant Production |
| title_fullStr | Harnessing Cyanobacteria’s Bioactive Potential: A Sustainable Strategy for Antioxidant Production |
| title_full_unstemmed | Harnessing Cyanobacteria’s Bioactive Potential: A Sustainable Strategy for Antioxidant Production |
| title_short | Harnessing Cyanobacteria’s Bioactive Potential: A Sustainable Strategy for Antioxidant Production |
| title_sort | harnessing cyanobacteria s bioactive potential a sustainable strategy for antioxidant production |
| topic | cyanobacteria <i>Anabaena</i> natural products mass spectrometry molecular network antioxidant |
| url | https://www.mdpi.com/2076-2607/12/1/175 |
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