Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study
Abstract Introduction We have conducted the pathological cohort study of autopsied cases of Hisayama residents to reveal a recent trend of dementia‐related pathology. We noticed a trend of putaminal involvement of Alzheimer's disease (AD) with parkinsonism. Then, we investigated the accurate pr...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-12-01
|
| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2019.04.008 |
| _version_ | 1818870610730680320 |
|---|---|
| author | Hideomi Hamasaki Hiroyuki Honda Satoshi O. Suzuki Masahiro Shijo Tomoyuki Ohara Yozo Hatabe Tsuyoshi Okamoto Toshiharu Ninomiya Toru Iwaki |
| author_facet | Hideomi Hamasaki Hiroyuki Honda Satoshi O. Suzuki Masahiro Shijo Tomoyuki Ohara Yozo Hatabe Tsuyoshi Okamoto Toshiharu Ninomiya Toru Iwaki |
| author_sort | Hideomi Hamasaki |
| collection | DOAJ |
| description | Abstract Introduction We have conducted the pathological cohort study of autopsied cases of Hisayama residents to reveal a recent trend of dementia‐related pathology. We noticed a trend of putaminal involvement of Alzheimer's disease (AD) with parkinsonism. Then, we investigated the accurate prevalence of neurological diseases with putaminal AD pathology in the general population. Methods We examined a series of 291 autopsies in the Hisayama study and performed image analysis of immunohistochemistry for microtubule‐associated protein tau (MAPT) and amyloid β. Results Approximately 65.6% and 36.1% of cases showed putaminal MAPT and amyloid deposits, respectively. Diffuse deposits of them were mainly found in the AD cases. Putaminal MAPT was highly associated with AD‐related pathological criteria. Four of 22 cases with severe putaminal MAPT deposition were documented as having developed parkinsonism. Discussion Severe MAPT accumulation in the basal ganglia was closely related to the development of AD pathology and could occur most frequently in AD cases without comorbidities. |
| first_indexed | 2024-12-19T12:09:46Z |
| format | Article |
| id | doaj.art-82e832d1c0c346ec94fb8fc1b0291f81 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-12-19T12:09:46Z |
| publishDate | 2019-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-82e832d1c0c346ec94fb8fc1b0291f812022-12-21T20:22:13ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292019-12-0111141542310.1016/j.dadm.2019.04.008Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama studyHideomi Hamasaki0Hiroyuki Honda1Satoshi O. Suzuki2Masahiro Shijo3Tomoyuki Ohara4Yozo Hatabe5Tsuyoshi Okamoto6Toshiharu Ninomiya7Toru Iwaki8Department of NeuropathologyGraduate School of Medical Sciences, Kyushu UniversityFukuokaJapanDepartment of NeuropathologyGraduate School of Medical Sciences, Kyushu UniversityFukuokaJapanDepartment of NeuropathologyGraduate School of Medical Sciences, Kyushu UniversityFukuokaJapanDepartment of NeuropathologyGraduate School of Medical Sciences, Kyushu UniversityFukuokaJapanDepartment of NeuropsychiatryGraduate School of Medical Sciences, Kyushu UniversityFukuokaJapanDepartment of NeuropsychiatryGraduate School of Medical Sciences, Kyushu UniversityFukuokaJapanFaculty of Arts and ScienceKyushu UniversityFukuokaJapanDepartment of Epidemiology and Public HealthGraduate School of Medical Sciences, Kyushu UniversityFukuokaJapanDepartment of NeuropathologyGraduate School of Medical Sciences, Kyushu UniversityFukuokaJapanAbstract Introduction We have conducted the pathological cohort study of autopsied cases of Hisayama residents to reveal a recent trend of dementia‐related pathology. We noticed a trend of putaminal involvement of Alzheimer's disease (AD) with parkinsonism. Then, we investigated the accurate prevalence of neurological diseases with putaminal AD pathology in the general population. Methods We examined a series of 291 autopsies in the Hisayama study and performed image analysis of immunohistochemistry for microtubule‐associated protein tau (MAPT) and amyloid β. Results Approximately 65.6% and 36.1% of cases showed putaminal MAPT and amyloid deposits, respectively. Diffuse deposits of them were mainly found in the AD cases. Putaminal MAPT was highly associated with AD‐related pathological criteria. Four of 22 cases with severe putaminal MAPT deposition were documented as having developed parkinsonism. Discussion Severe MAPT accumulation in the basal ganglia was closely related to the development of AD pathology and could occur most frequently in AD cases without comorbidities.https://doi.org/10.1016/j.dadm.2019.04.008MAPTTauBasal ganglionAlzheimer's diseaseParkinsonism |
| spellingShingle | Hideomi Hamasaki Hiroyuki Honda Satoshi O. Suzuki Masahiro Shijo Tomoyuki Ohara Yozo Hatabe Tsuyoshi Okamoto Toshiharu Ninomiya Toru Iwaki Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring MAPT Tau Basal ganglion Alzheimer's disease Parkinsonism |
| title | Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study |
| title_full | Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study |
| title_fullStr | Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study |
| title_full_unstemmed | Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study |
| title_short | Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study |
| title_sort | tauopathy in basal ganglia involvement is exacerbated in a subset of patients with alzheimer s disease the hisayama study |
| topic | MAPT Tau Basal ganglion Alzheimer's disease Parkinsonism |
| url | https://doi.org/10.1016/j.dadm.2019.04.008 |
| work_keys_str_mv | AT hideomihamasaki tauopathyinbasalgangliainvolvementisexacerbatedinasubsetofpatientswithalzheimersdiseasethehisayamastudy AT hiroyukihonda tauopathyinbasalgangliainvolvementisexacerbatedinasubsetofpatientswithalzheimersdiseasethehisayamastudy AT satoshiosuzuki tauopathyinbasalgangliainvolvementisexacerbatedinasubsetofpatientswithalzheimersdiseasethehisayamastudy AT masahiroshijo tauopathyinbasalgangliainvolvementisexacerbatedinasubsetofpatientswithalzheimersdiseasethehisayamastudy AT tomoyukiohara tauopathyinbasalgangliainvolvementisexacerbatedinasubsetofpatientswithalzheimersdiseasethehisayamastudy AT yozohatabe tauopathyinbasalgangliainvolvementisexacerbatedinasubsetofpatientswithalzheimersdiseasethehisayamastudy AT tsuyoshiokamoto tauopathyinbasalgangliainvolvementisexacerbatedinasubsetofpatientswithalzheimersdiseasethehisayamastudy AT toshiharuninomiya tauopathyinbasalgangliainvolvementisexacerbatedinasubsetofpatientswithalzheimersdiseasethehisayamastudy AT toruiwaki tauopathyinbasalgangliainvolvementisexacerbatedinasubsetofpatientswithalzheimersdiseasethehisayamastudy |