NLRC5, AT THE HEART OF ANTIGEN PRESENTATION
Nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are intracellular proteins mainly involved in pathogen recognition, inflammatory responses, and cell death. Until recently, the function of the family member NLR caspase recruitment domain (CARD) containing 5 (NLRC5) has b...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00397/full |
| _version_ | 1811212300559843328 |
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| author | Andreas eNeerincx Wilson eCastro Greta eGuarda Thomas A. Kufer |
| author_facet | Andreas eNeerincx Wilson eCastro Greta eGuarda Thomas A. Kufer |
| author_sort | Andreas eNeerincx |
| collection | DOAJ |
| description | Nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are intracellular proteins mainly involved in pathogen recognition, inflammatory responses, and cell death. Until recently, the function of the family member NLR caspase recruitment domain (CARD) containing 5 (NLRC5) has been a matter of debate. It is now clear that NLRC5 acts as a transcriptional regulator of the major-histocompatibility complex (MHC) class I. In this review we detail the development of our understanding of NLRC5 function, discussing both the accepted and the controversial aspects of NLRC5 activity. We give insight into the molecular mechanisms, and the potential implications, of NLRC5 function in health and disease. |
| first_indexed | 2024-04-12T05:26:53Z |
| format | Article |
| id | doaj.art-82e834e0b9914ec999cbbaea1f1845e8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T05:26:53Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-82e834e0b9914ec999cbbaea1f1845e82022-12-22T03:46:15ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-11-01410.3389/fimmu.2013.0039763745NLRC5, AT THE HEART OF ANTIGEN PRESENTATIONAndreas eNeerincx0Wilson eCastro1Greta eGuarda2Thomas A. Kufer3University of CologneUniversity of LausanneUniversity of LausanneUniversity of CologneNucleotide-binding domain and leucine-rich repeat containing receptors (NLRs) are intracellular proteins mainly involved in pathogen recognition, inflammatory responses, and cell death. Until recently, the function of the family member NLR caspase recruitment domain (CARD) containing 5 (NLRC5) has been a matter of debate. It is now clear that NLRC5 acts as a transcriptional regulator of the major-histocompatibility complex (MHC) class I. In this review we detail the development of our understanding of NLRC5 function, discussing both the accepted and the controversial aspects of NLRC5 activity. We give insight into the molecular mechanisms, and the potential implications, of NLRC5 function in health and disease.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00397/fullAntigen PresentationNuclear ProteinsTranscription, GeneticMHC class IDisease Models, AnimalNLR |
| spellingShingle | Andreas eNeerincx Wilson eCastro Greta eGuarda Thomas A. Kufer NLRC5, AT THE HEART OF ANTIGEN PRESENTATION Frontiers in Immunology Antigen Presentation Nuclear Proteins Transcription, Genetic MHC class I Disease Models, Animal NLR |
| title | NLRC5, AT THE HEART OF ANTIGEN PRESENTATION |
| title_full | NLRC5, AT THE HEART OF ANTIGEN PRESENTATION |
| title_fullStr | NLRC5, AT THE HEART OF ANTIGEN PRESENTATION |
| title_full_unstemmed | NLRC5, AT THE HEART OF ANTIGEN PRESENTATION |
| title_short | NLRC5, AT THE HEART OF ANTIGEN PRESENTATION |
| title_sort | nlrc5 at the heart of antigen presentation |
| topic | Antigen Presentation Nuclear Proteins Transcription, Genetic MHC class I Disease Models, Animal NLR |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00397/full |
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